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Proceedings Paper

Intravascular Application Of Hematoporphyrin Derivative Photodynamic Therapy
Author(s): Artur M. Spokojny; Donna Bourgelais; Juan R. Serur; S. Paulin; J.Richard Spears
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Paper Abstract

Photodynamic therapy (PDT) of diseased tissues with hematoporphyrin derivative (HPD) within the cardiovascular system could be performed with a light-emitting antra-arterial optical fiber. However, the penetration of light at 631 nm through oxygenated whole blood first needs to be studied. In vitro studies were, therefore, performed to measure the transmission of 631 nm light, generated by an argon-ion pumped dye laser, through whole blood and serial dilutions of whole blood with the relatively translucent blood substitute Fluosol-DA. The results indicate that whole blood attenuates 631 nm light far greater than tissues, where HPD-PDT is currently applied, and that a 2 mm thickness of whole blood at a normal hematocrit may prevent a photodynamic tissue reaction when a conventional light dose is applied. Preliminary observations in rabbits treated in vivo with hematoporphyrin and 631 nm light via an intra-aortic optical fiber, with and without Fluosol-DA hemodilution, confirm these results. Hemodilution of whole blood with translucent liquids will enhance photodynamic tissue reactions and may be a necessary adjunct when this therapy is applied within the cardiovascular system.

Paper Details

Date Published: 24 October 1984
PDF: 7 pages
Proc. SPIE 0494, Novel Optical Fiber Techniques for Medical Applications, (24 October 1984); doi: 10.1117/12.943910
Show Author Affiliations
Artur M. Spokojny, Beth Israel Hospital and Harvard Medical School (United States)
Donna Bourgelais, Beth Israel Hospital and Harvard Medical School (United States)
Juan R. Serur, Harvard Medical School (United States)
S. Paulin, Harvard Medical School (United States)
J.Richard Spears, Beth Israel Hospital and Harvard Medical School (United States)

Published in SPIE Proceedings Vol. 0494:
Novel Optical Fiber Techniques for Medical Applications
Abraham Katzir, Editor(s)

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