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Proceedings Paper

Hydrophobic Versus Hydrophilic Drugs For PDT
Author(s): Alan R. Morgan; Greta M. Garbo; Rick W. Keck; Steven H. Selman
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Paper Abstract

In recent years, a number of new photosensitizers have been developed for the photo-dynamic treatment of cancer. These new drugs include tetrasulfonated phthalocyanines, tetra(hydroxypheny1) porphyrins, chlorins and purpurins which are water soluble, and phthalocyanines, chlorins, purpurins and verdins which are water insoluble. In vivo or in vitro data are available to assess the relative photodynamic efficiency of either hydrophobic or hydrophilic sensitizers. Hydrophobic drugs require a more complex delivery system in order to overcome their water insolubility. In this paper, we report the suitability of both oil-based emulsions and unilamellar liposomes for in vivo delivery of three different photosensitizers (a purpurin, a verdin and a chlorin).

Paper Details

Date Published: 19 February 1988
PDF: 7 pages
Proc. SPIE 0847, New Directions in Photodynamic Therapy, (19 February 1988); doi: 10.1117/12.942709
Show Author Affiliations
Alan R. Morgan, University of Toledo (United States)
Greta M. Garbo, University of Toledo (United States)
Rick W. Keck, Medical College of Ohio (United States)
Steven H. Selman, Medical College of Ohio (United States)

Published in SPIE Proceedings Vol. 0847:
New Directions in Photodynamic Therapy
Douglas C. Neckers, Editor(s)

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