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Proceedings Paper

Liposomes As Carriers Of Hydrophobic Photosensitizers In Vivo: Increased Selectivity Of Tumor Targeting
Author(s): Fernanda Ricchelli; Roberta Biolo; Elena Reddi; Giuseppe Tognon; Giulio Jori
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Paper Abstract

Unilamellar liposomes of dipalmitoyl-phosphatidylcholine (DPPC) incorporate a variety of hydrophobic photosensitizers (e.g. hematoporphyrin dimethylester, unsubstituted phthalo-cyanines, porphycene) into the phospholipid bilayer. The physico-chemical properties of the liposome-bound photosensitizers in the ground and electronically excited states can be characterized by steady-state and time-resolved fluorescence spectroscopy. The liposome-drug system is stable under physiological conditions and, once injected into tumor-bearing animals, selectively delivers the photosensitizer to serum lipoproteins. As a consequence, the tumor uptake of the drug via receptor-mediated endocytosis of low-density lipoproteins (LDL) is favoured. This leads to a larger ratio between the photosensitizer concentration in the tumor and adjacent normal tissues, hence to an increased efficacy of the photodynamic therapy (PDT).

Paper Details

Date Published: 19 February 1988
PDF: 6 pages
Proc. SPIE 0847, New Directions in Photodynamic Therapy, (19 February 1988); doi: 10.1117/12.942696
Show Author Affiliations
Fernanda Ricchelli, University of Padova (Italy)
Roberta Biolo, University of Padova (Italy)
Elena Reddi, University of Padova (Italy)
Giuseppe Tognon, University of Padova (Italy)
Giulio Jori, University of Padova (Italy)

Published in SPIE Proceedings Vol. 0847:
New Directions in Photodynamic Therapy
Douglas C. Neckers, Editor(s)

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