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Proceedings Paper

Characterization Of Oligomeric Hematoporphyrin Tumoricidal Reagents For Photodynamic Therapy
Author(s): Brian Musselman; Chi K. Chang
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Paper Abstract

The primary structure of the tumor-localizing component of Hematoporphyrin Derivative (HPD) has been shown by fast atom bombardment (FAB) mass spectrometry to consist of hematoporphyrin (HP)-based oligomers of up to five subunits with a general formula of nHP-(n-1)H2O. The nature of the covalent bond linking the porphyrin units has been probed by LiA1H4-reduction and by diazomethane-permethylation of the oligomer-containing fraction of the drug. Results suggest that both ether and ester groups are present and that the composition may be dependent on the shelf-life and the preparative method employed. Cell assay with HPD preparations enriched in ether or ester content indicates that variations of the linkage between porphyrin units have essentially no effect on the photodynamic activity.

Paper Details

Date Published: 19 February 1988
PDF: 5 pages
Proc. SPIE 0847, New Directions in Photodynamic Therapy, (19 February 1988); doi: 10.1117/12.942695
Show Author Affiliations
Brian Musselman, Michigan State University (United States)
Chi K. Chang, Michigan State University (United States)

Published in SPIE Proceedings Vol. 0847:
New Directions in Photodynamic Therapy
Douglas C. Neckers, Editor(s)

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