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Proceedings Paper

Assessing Hyperthermic Treatment Success By Two Dimensional Ultrasound Textural Analysis
Author(s): A. M. Youssef; D. Schlaps; I. Zuna; G. Van Kaick; W. J. Lorenz
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Paper Abstract

In hyperthermia treatment, ability to predict complete tissue temperature fields from a limited sampled temperatures or non invasively is greatly desirable to assess treatment success. Non uniform heating of the lesion causes less pronounced cell kill in inadequately heated regions. Tissues were suspended in a temperature controlled water bath, the temperature of the bath is increased at different high rates to ensure no tissue variations. Two thermistors were inserted at the upper and lower edges of the region of interest (ROI) with-in the tissue sample. A real time sector ultrasound image along with the radio frequency signal are accessed in real time at different temperatures of the (ROI). First and second order grey level statistics were calculated for fresh liver kidney and brain (cow) tissues in the temperature range of 32-47°C. The average temperature in the (ROI) is correlated with the calculated parameters. Entropy is a sensitive parameter to assess the uniformity of heating. Possibility of in vivo study, and to predict long term hyperthermic effects via the calculation of backscattering coefficient is further investigated. A multi-layered model is also presented to aid in spatially resolving temperature dependent acoustic parameters.

Paper Details

Date Published: 10 September 1987
PDF: 11 pages
Proc. SPIE 0768, Pattern Recognition and Acoustical Imaging, (10 September 1987); doi: 10.1117/12.940259
Show Author Affiliations
A. M. Youssef, German Cancer Research Center (FRG)
D. Schlaps, German Cancer Research Center (FRG)
I. Zuna, German Cancer Research Center (FRG)
G. Van Kaick, German Cancer Research Center (FRG)
W. J. Lorenz, German Cancer Research Center (FRG)

Published in SPIE Proceedings Vol. 0768:
Pattern Recognition and Acoustical Imaging
Leonard A. Ferrari, Editor(s)

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