The continuous measurement of intratissular NADH concentration allows early detection of cellular respiration arrest during clinical situations, i.e. allows a non-destructive, in situ, continuous measurement of ATP formation. This detection enables the physician or surgeon to intervene during a phase of cellular respiration arrest, before structural cellular alterations occur, thereby preventing potential tissular necrosis. The method has now been validated in experimental cardiac surgery for the monitoring of myocardial preservation techniques in cardiopulmonary by-pass and in cardiac pharmacology. Its industrial development is currently under way. Preliminary investigation strongly suggest the vast potentials of this diagnostic method in both clinical and experimental fields.

Date Published: 1 April 1987
PDF: 8 pages
Proc. SPIE 0713, Optical Fibers in Medicine II, (1 April 1987); doi: 10.1117/12.937388

Published in SPIE Proceedings Vol. 0713:
Optical Fibers in Medicine II
Abraham Katzir, Editor(s)