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Proceedings Paper

In Situ Detection Of Tissular Respiration Arrest By NADH Laser Fluorimetry
Author(s): Guy Renault; Martine Muffat-Joly; Juliette Polianski; Roger Ian Hardy; Remy Nottin; Michel Weiss; Jean-Louis Boutineau; Jean-Paul Binet; Jean-Jacques Pocidalo
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Paper Abstract

The continuous measurement of intratissular NADH concentration allows early detection of cellular respiration arrest during clinical situations, i.e. allows a non-destructive, in situ, continuous measurement of ATP formation. This detection enables the physician or surgeon to intervene during a phase of cellular respiration arrest, before structural cellular alterations occur, thereby preventing potential tissular necrosis. The method has now been validated in experimental cardiac surgery for the monitoring of myocardial preservation techniques in cardiopulmonary by-pass and in cardiac pharmacology. Its industrial development is currently under way. Preliminary investigation strongly suggest the vast potentials of this diagnostic method in both clinical and experimental fields.

Paper Details

Date Published: 1 April 1987
PDF: 8 pages
Proc. SPIE 0713, Optical Fibers in Medicine II, (1 April 1987); doi: 10.1117/12.937388
Show Author Affiliations
Guy Renault, Hopital Claude Bernard (France)
Martine Muffat-Joly, Hopital Claude Bernard (France)
Juliette Polianski, Hopital Claude Bernard (France)
Roger Ian Hardy, Children's Hospital Medical Center (France)
Remy Nottin, Centre Chirurgical Marie-Lannelongue (France)
Michel Weiss, Centre Chirurgical Marie-Lannelongue (France)
Jean-Louis Boutineau, CILAS-ALCATEL (France)
Jean-Paul Binet, Centre Chirurgical Marie-Lannelongue (France)
Jean-Jacques Pocidalo, Hopital Claude Bernard (France)

Published in SPIE Proceedings Vol. 0713:
Optical Fibers in Medicine II
Abraham Katzir, Editor(s)

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