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Proceedings Paper

Pulse Width Dependence Of Pigment Cell Damage At 694 nm In Guinea Pig Skin
Author(s): Jeffrey S. Dover; Luigi L. Polla; Randall J. Margolis; Diana Whitaker; Schinichi Watanabe; George F. Murphy; John A. Parrish; R. Rox Anderson
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Paper Abstract

351 nm, 20-nsec XeF excimer laser irradiation has previously been shown to selectively target and damage melanosomes in human skin. In the following studies selective targeting with melanosomal photodisruption has been demonstrated in pigmented guinea pig skin with a Q-switched 40-nsec ruby laser, and a 750-nsec pulsed dye laser but not with a 400-usec pulsed dye laser. The pulse width dependence of melanosomal disruption, occurring only at pulsewidths shorter than the thermal relaxation time of the melanosome (0.5 - 1.0 usec), is in accordance with the theory of selective photothermolysis. Possible mechanisms of melanosomal photodisruption include development of sudden thermal gradients leading to cavitation or shock wave production.

Paper Details

Date Published: 10 March 1987
PDF: 6 pages
Proc. SPIE 0712, Lasers in Medicine, (10 March 1987);
Show Author Affiliations
Jeffrey S. Dover, Harvard Medical Scnool (United States)
Luigi L. Polla, Harvard Medical Scnool (United States)
Randall J. Margolis, Harvard Medical Scnool (United States)
Diana Whitaker, Harvard Medical Scnool (United States)
Schinichi Watanabe, Harvard Medical Scnool (United States)
George F. Murphy, Harvard Medical Scnool (United States)
John A. Parrish, Harvard Medical Scnool (United States)
R. Rox Anderson, Harvard Medical Scnool (United States)

Published in SPIE Proceedings Vol. 0712:
Lasers in Medicine
Stephen N. Joffe M.D.; John A. Parrish M.D., Editor(s)

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