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Proceedings Paper

Porphyrin Fluorescence: Gross And Microscopic Localization
Author(s): David M. Harris; James H. Hill
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Paper Abstract

Hematoporphyrin derivative (HPD) is a mixture of porphyrins that localize in malignant tumors. The fluorescent emission of HPD was used in three animal tumor models to define tumor margins with gross imaging and to identify the microscopic distribution with fluores-cent photomicroscopy combined with standard histology. Fibroblasts within the tumor stroma were identified as the main cellular element retaining HPD. Our data indicate a barrier to diffusion of HPD containing it within the connective tissue capsule and preventing its up-take by malignant cells. A model for the uptake, retention and photodynamic action of HPD on tumors is proposed.

Paper Details

Date Published: 10 March 1987
PDF: 6 pages
Proc. SPIE 0712, Lasers in Medicine, (10 March 1987); doi: 10.1117/12.937320
Show Author Affiliations
David M. Harris, Ravenswood Hospital Medical Center and University of Illinois College of Medicine (United States)
James H. Hill, University of Illinois College of Medicine and West Side Veterans Administration Medical Center (United States)

Published in SPIE Proceedings Vol. 0712:
Lasers in Medicine
Stephen N. Joffe M.D.; John A. Parrish M.D., Editor(s)

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