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Proceedings Paper

Single-layer graphene based SPR biochips for tuberculosis bacillus detection
Author(s): Nan-Fu Chiu; Teng-Yi Huang; Chun-Chuan Kuo; Wei-Che Lee; Min-Hua Hsieh; Hsin-Chih Lai
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Paper Abstract

This paper is intended to demonstrate a facile and effective method to construct single layer graphene films onto the self-assembled monolayer (SAM) at Au electrodes based surface plasmon resonance (SPR) biochips integrated loop-mediated isothermal amplification (LAMP) for tuberculosis bacillus (TB) detection. It is a novel Au-SAM-graphene nanocomposites and taking advantages of the striking properties of both graphene and Au film, fundamental understanding in hybrid material manipulation and new electrochemical properties can be obtained. The sensitivity of TB detection in the LAMP-based assay for the amplification of the Insertion Sequence 6110 (IS6110) samples was determined by a single-layer graphene/Au thin film and compared with that of a conventional Au/Cr-based SPR chips. The results show that a graphene/Au SPR offers a potentially powerful assay, with a highly sensitive analysis, that may be applicable as an important tool for bio-marker detection.

Paper Details

Date Published: 8 May 2012
PDF: 7 pages
Proc. SPIE 8427, Biophotonics: Photonic Solutions for Better Health Care III, 84273M (8 May 2012); doi: 10.1117/12.922698
Show Author Affiliations
Nan-Fu Chiu, National Taiwan Normal Univ. (Taiwan)
Teng-Yi Huang, National Taiwan Normal Univ. (Taiwan)
Chun-Chuan Kuo, National Taiwan Normal Univ. (Taiwan)
Wei-Che Lee, National Taiwan Normal Univ. (Taiwan)
Min-Hua Hsieh, Chang Gung Univ. (Taiwan)
Hsin-Chih Lai, Chang Gung Univ. (Taiwan)

Published in SPIE Proceedings Vol. 8427:
Biophotonics: Photonic Solutions for Better Health Care III
Jürgen Popp; Wolfgang Drexler; Valery V. Tuchin; Dennis L. Matthews, Editor(s)

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