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Proceedings Paper

Layered polymer: inorganic composite waveguides for biosensor applications
Author(s): Jussi Hiltunen; Meng Wang; Christina Liedert; Sanna Aikio; Noriyuki Masuda; Stuart Pearce; Martin Charlton; Pentti Karioja
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Paper Abstract

In this work, we investigate the usability of layered polymer - inorganic composite waveguides for label-free sensing of surface bound bioreactions in an aqueous environment. The waveguide structure consists of a nanoimprint fabricated polymeric inverted rib waveguide with a sputtered Ta2O5 thin film on top. The interaction of the optical field with the surface is increased as a consequence of the mode profile localization near the surface, when high-index coating is deposited on a low-index waveguide. Young interferometer configuration with reference and sensors waveguide arms was utilized in sensor chips. Light from a laser source was end-fire coupled into the chips and interference pattern produced by the outcoupled light was investigated. External μ-fluidic pump was used to produce the analyte flow. Ambient refractive index change was characterized by applying DI-water with varying glucose concentration on waveguides. With the waveguide length of 1 cm a detection limit in the order of 10-7 - 10-6 refractive index unit (RIU) was achieved. Specific binding reactions on the surface were investigated with C - reactive protein (CRP) antibodies and antigens.

Paper Details

Date Published: 8 May 2012
PDF: 6 pages
Proc. SPIE 8427, Biophotonics: Photonic Solutions for Better Health Care III, 84270I (8 May 2012); doi: 10.1117/12.922267
Show Author Affiliations
Jussi Hiltunen, VTT Technical Research Ctr. of Finland (Finland)
Meng Wang, Univ. of Oulu (Finland)
Christina Liedert, VTT Technical Research Ctr. of Finland (Finland)
Sanna Aikio, VTT Technical Research Ctr. of Finland (Finland)
Noriyuki Masuda, VTT Technical Research Ctr. of Finland (Finland)
Stuart Pearce, Univ. of Southampton (United Kingdom)
Martin Charlton, Univ. of Southampton (United Kingdom)
Pentti Karioja, VTT Technical Research Ctr. of Finland (Finland)

Published in SPIE Proceedings Vol. 8427:
Biophotonics: Photonic Solutions for Better Health Care III
Jürgen Popp; Wolfgang Drexler; Valery V. Tuchin; Dennis L. Matthews, Editor(s)

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