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Proceedings Paper

Highly sensitive detection of glucose concentration with opto-fluidics ring resonator
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Paper Abstract

Noninvasive detection of glucose has been heavily researched in their roles of offering cost-effective, painless, and bloodless monitoring of glucose concentration. In this work, we describe a novel, label-free, and sensitive approach for detecting the glucose concentration in human interstitial fluid samples using the opto-fluidic ring resonator (OFRR). The OFRR incorporates microfluidics and optical ring resonator sensing technology to achieve rapid label-free detection in a small and low-cost platform. In this study, bulk refractive index measurements are presented. Results show that the OFRR is able to detect glucose at medically relevant concentrations in interstitial fluid ranging from 0 to 25 mM, with a detection limit of 0.32 mM, which is lower than clinical requirement by one order of magnitude. Our work is believed to lead to a device that can be used to frequently monitor glucose concentration in a low-cost and painless manner.

Paper Details

Date Published: 19 May 2012
PDF: 6 pages
Proc. SPIE 8376, Photonic Microdevices/Microstructures for Sensing IV, 83760C (19 May 2012); doi: 10.1117/12.921102
Show Author Affiliations
Yunhan Luo, Jinan Univ. (China)
Univ. of Michigan, Ann Arbor (United States)
Maung Kyaw Khaing Oo, Univ. of Michigan, Ann Arbor (United States)
Jia Ge, Jinan Univ. (China)
Zhe Chen, Jinan Univ. (China)
Xudong Fan, Univ. of Michigan, Ann Arbor (United States)

Published in SPIE Proceedings Vol. 8376:
Photonic Microdevices/Microstructures for Sensing IV
Xudong Fan; Hai Xiao; Anbo Wang, Editor(s)

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