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Proceedings Paper

Ultra-thin layer chromatography and surface enhanced Raman spectroscopy on silver nanorod array substrates prepared by oblique angle deposition
Author(s): Jing Chen; Justin Abell; Yao-wen Huang; Yiping Zhao
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Paper Abstract

We demonstrate the potential use of silver nanorod (AgNR) array substrates for on-chip separation and detection of chemical mixtures by ultra-thin layer chromatography (UTLC) and surface enhanced Raman spectroscopy (SERS). The capability of the AgNR substrates to separate different compounds in a mixture was explored using a mixture of the food colorant Brilliant Blue FCF and lactic acid, and the mixtures of Methylene Violet and BSA at various concentrations. After the UTLC process, spatially-resolved SERS spectra were collected along the mobile phase development direction and the intensities of specific SERS peaks from each component were used to generate chromatograms. The AgNR substrates demonstrate the capability of separating Brilliant Blue from lactic acid, as well as revealing the SERS signal of Methylene Violet from the massive BSA background after a simple UTLC step. This technique may have significant practical implications in actual detection of small molecules from complex food or clinical backgrounds.

Paper Details

Date Published: 9 May 2012
PDF: 8 pages
Proc. SPIE 8366, Advanced Environmental, Chemical, and Biological Sensing Technologies IX, 836605 (9 May 2012); doi: 10.1117/12.918763
Show Author Affiliations
Jing Chen, The Univ. of Georgia (United States)
Justin Abell, The Univ. of Georgia (United States)
Yao-wen Huang, The Univ. of Georgia (United States)
Yiping Zhao, The Univ. of Georgia (United States)


Published in SPIE Proceedings Vol. 8366:
Advanced Environmental, Chemical, and Biological Sensing Technologies IX
Tuan Vo-Dinh; Robert A. Lieberman; Günter Gauglitz, Editor(s)

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