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Proceedings Paper

Sensitivity enhancement and detection-limit improvement in whispering-gallery-mode-based biosensing
Author(s): Bei-Bei Li; Xu Yi; Qiu-Shu Chen; Yong-Chun Liu; Yun-Feng Xiao
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Paper Abstract

In whispering-gallery-mode (WGM) microresonator based optical biosensors, the mode shift or splitting induced by biomolecules are typically regarded as the sensing signals. Here we propose several schemes to improve the performance of WGM based biosensing. In the mode shift sensing scheme, we propose to use a novel exterior plasmonic WGM supported by a metal-coated toroidal microresonator, and the detection sensitivity reaches 500 nm/RIU (refraction index unit). In the mode splitting scheme, we study and discuss how to extend the detection range, which is of importance in detecting small-sized biomolecules. Finally, the single nanoparticle detection is realized experimentally by using mode splitting sensing scheme in the aqueous environment.

Paper Details

Date Published: 19 May 2012
PDF: 12 pages
Proc. SPIE 8376, Photonic Microdevices/Microstructures for Sensing IV, 837607 (19 May 2012); doi: 10.1117/12.918401
Show Author Affiliations
Bei-Bei Li, Peking Univ. (China)
Xu Yi, Peking Univ. (China)
Qiu-Shu Chen, Peking Univ. (China)
Yong-Chun Liu, Peking Univ. (China)
Yun-Feng Xiao, Peking Univ. (China)

Published in SPIE Proceedings Vol. 8376:
Photonic Microdevices/Microstructures for Sensing IV
Xudong Fan; Hai Xiao; Anbo Wang, Editor(s)

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