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Proceedings Paper

Synthesis and characterization of fluorescent dyes-magnetic nanoparticles for bioimaging applications
Author(s): Swee Kuan Yen; Dominik Jańczewski; Surani Bin Dolmanan; Tripathy Sudhiranjan; Subramanian Tamil Selvan
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Paper Abstract

Magnetic-fluorescent nanoparticles have been emerging as potential bimodal probes in the area of bioimaging. However, near-infrared (NIR) fluorescent dye as a fluorescent material for bimodal probe remains unexplored. The tailor-design of NIR cyanine dye is challenging. Herein, we report the synthesis and characterization of novel functional IR 820 dye. This modified IR 820 has been successfully conjugated with long and short back-bone chain polymers. All these compounds preserve good water solubility and photochemical properties. The magnetic-fluorescent bimodal probe has been demonstrated, wherein the magnetic nanoparticles have been coated with dye-polymer. The cytotoxicity studies on HeLa cells show that MNP@dye-polymer with short back-bone chain has better cell viability.

Paper Details

Date Published: 2 February 2012
PDF: 7 pages
Proc. SPIE 8232, Colloidal Nanocrystals for Biomedical Applications VII, 82320L (2 February 2012); doi: 10.1117/12.917325
Show Author Affiliations
Swee Kuan Yen, A*STAR Institute of Materials Research and Engineering (Singapore)
Dominik Jańczewski, A*STAR Institute of Materials Research and Engineering (Singapore)
Surani Bin Dolmanan, A*STAR Institute of Materials Research and Engineering (Singapore)
Tripathy Sudhiranjan, A*STAR Institute of Materials Research and Engineering (Singapore)
Subramanian Tamil Selvan, A*STAR Institute of Materials Research and Engineering (Singapore)


Published in SPIE Proceedings Vol. 8232:
Colloidal Nanocrystals for Biomedical Applications VII
Wolfgang J. Parak; Kenji Yamamoto M.D.; Marek Osinski, Editor(s)

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