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Proceedings Paper

Registration of 3D spectral OCT volumes combining ICP with a graph-based approach
Author(s): Meindert Niemeijer; Kyungmoo Lee; Mona K. Garvin; Michael D. Abràmoff; Milan Sonka
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Paper Abstract

The introduction of spectral Optical Coherence Tomography (OCT) scanners has enabled acquisition of high resolution, 3D cross-sectional volumetric images of the retina. 3D-OCT is used to detect and manage eye diseases such as glaucoma and age-related macular degeneration. To follow-up patients over time, image registration is a vital tool to enable more precise, quantitative comparison of disease states. In this work we present a 3D registrationmethod based on a two-step approach. In the first step we register both scans in the XY domain using an Iterative Closest Point (ICP) based algorithm. This algorithm is applied to vessel segmentations obtained from the projection image of each scan. The distance minimized in the ICP algorithm includes measurements of the vessel orientation and vessel width to allow for a more robust match. In the second step, a graph-based method is applied to find the optimal translation along the depth axis of the individual A-scans in the volume to match both scans. The cost image used to construct the graph is based on the mean squared error (MSE) between matching A-scans in both images at different translations. We have applied this method to the registration of Optic Nerve Head (ONH) centered 3D-OCT scans of the same patient. First, 10 3D-OCT scans of 5 eyes with glaucoma imaged in vivo were registered for a qualitative evaluation of the algorithm performance. Then, 17 OCT data set pairs of 17 eyes with known deformation were used for quantitative assessment of the method's robustness.

Paper Details

Date Published: 14 February 2012
PDF: 9 pages
Proc. SPIE 8314, Medical Imaging 2012: Image Processing, 83141A (14 February 2012); doi: 10.1117/12.911104
Show Author Affiliations
Meindert Niemeijer, The Univ. of Iowa (United States)
Kyungmoo Lee, The Univ. of Iowa (United States)
Mona K. Garvin, The Univ. of Iowa (United States)
Veterans Affairs Medical Ctr. (United States)
Michael D. Abràmoff, The Univ. of Iowa (United States)
Veterans Affairs Medical Ctr. (United States)
Milan Sonka, The Univ. of Iowa (United States)

Published in SPIE Proceedings Vol. 8314:
Medical Imaging 2012: Image Processing
David R. Haynor; Sébastien Ourselin, Editor(s)

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