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Proceedings Paper

Model-based blood flow quantification from DSA: quantitative evaluation on patient data and comparison with TCCD
Author(s): I. Waechter-Stehle; A. Groth; T. Bruijns; O. Brina; D. A. Ruefenacht; Z. Kulcsar; V. Mendes-Pereira; F. Perren; D. J. Hawkes; J. Weese
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Paper Abstract

Purpose: To support intra-interventional decisions on diagnosis and treatment of cerebrovascular diseases, a method providing quantitative information about the blood flow in the vascular system is proposed. Method: This method combines rotational angiography to extract the 3D vessel geometry and digital subtraction angiography (DSA) to obtain the flow observations. A physical model of blood flow and contrast agent transport is used to predict the propagation of the contrast agent through the vascular system. In an iterative approach, the model parameters, including the volumetric blood flow rate, are adapted until the prediction matches the observations from the DSA. The flow estimation method was applied to patient data: For 24 patients, the volumetric blood flow rate was determined from angiographic images and for 17 patients, results were compared with transcranial color coded Doppler (TCCD) measurements. Results: The agreement of the x-ray based flow estimates with TCCD was reasonable (bias ΔM = 3%, correlation ρ = 0.76) and reproducibility was clearly better than the reproducibility of the acquired TCCD measurements. Conclusion: Overall we conclude that it is feasible to model the contrast agent transport in patients and to utilize the flow model to quantify their blood flow with angiographic means.

Paper Details

Date Published: 24 February 2012
PDF: 17 pages
Proc. SPIE 8314, Medical Imaging 2012: Image Processing, 83144R (24 February 2012); doi: 10.1117/12.911095
Show Author Affiliations
I. Waechter-Stehle, Philips Research Labs. (Germany)
A. Groth, Philips Research Labs. (Germany)
T. Bruijns, Philips Healthcare (Netherlands)
O. Brina, Univ. Hospital of Geneva (Switzerland)
D. A. Ruefenacht, Clinic Hirslanden (Switzerland)
Z. Kulcsar, Clinic Hirslanden (Switzerland)
V. Mendes-Pereira, Univ. Hospital of Geneva (Switzerland)
F. Perren, Univ. Hospital of Geneva (Switzerland)
D. J. Hawkes, Univ. College London (United Kingdom)
J. Weese, Philips Research Labs. (Germany)

Published in SPIE Proceedings Vol. 8314:
Medical Imaging 2012: Image Processing
David R. Haynor; Sébastien Ourselin, Editor(s)

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