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Proceedings Paper

Lab-on-a-chip sensor for measuring Zn by stripping voltammetry
Author(s): Xing Pei; Wenjing Kang; Wei Yue; Adam Bange; Hector R. Wong; William R. Heineman; Ian Papautsky
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Paper Abstract

This work reports on continuing development of a lab-on-a-chip sensor for electrochemical detection of heavy metal zinc in blood serum. The sensor consists of a three electrode system, including an environmentally-friendly bismuth working electrode, a Ag/AgCl reference electrode, and a gold auxiliary electrode. By optimizing the electrodeposition of bismuth film, better control of fabrication steps and improving interface between the sensor and potentiostat, repeatability and sensitivity of the lab-on-a-chip sensor has been improved. Through optimization of electrolyte and stripping voltammetry parameters, limits of detection were greatly improved. The optimized sensor was able to measure zinc in in the physiological range of 65-95 μg/dL. Ultimately, with further development and integrated sample preparation sensor system will permit rapid (min) measurements of zinc from a sub-mL sample (a few drops of blood) for bedside monitoring.

Paper Details

Date Published: 14 February 2012
PDF: 8 pages
Proc. SPIE 8251, Microfluidics, BioMEMS, and Medical Microsystems X, 82510K (14 February 2012); doi: 10.1117/12.910621
Show Author Affiliations
Xing Pei, Univ. of Cincinnati (United States)
Wenjing Kang, Univ. of Cincinnati (United States)
Wei Yue, Univ. of Cincinnati (United States)
Adam Bange, Xavier Univ. (United States)
Hector R. Wong, Cincinnati Children's Hospital Medical Ctr. (United States)
William R. Heineman, Univ. of Cincinnati (United States)
Ian Papautsky, Univ. of Cincinnati (United States)

Published in SPIE Proceedings Vol. 8251:
Microfluidics, BioMEMS, and Medical Microsystems X
Holger Becker; Bonnie L. Gray, Editor(s)

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