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Proceedings Paper

Photon-counting spectral phase-contrast mammography
Author(s): E. Fredenberg; E. Roessl; T. Koehler; U. van Stevendaal; I. Schulze-Wenck; N. Wieberneit; M. Stampanoni; Z. Wang; R. A. Kubik-Huch; N. Hauser; M. Lundqvist; M. Danielsson; M. Åslund
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Paper Abstract

Phase-contrast imaging is an emerging technology that may increase the signal-difference-to-noise ratio in medical imaging. One of the most promising phase-contrast techniques is Talbot interferometry, which, combined with energy-sensitive photon-counting detectors, enables spectral differential phase-contrast mammography. We have evaluated a realistic system based on this technique by cascaded-systems analysis and with a task-dependent ideal-observer detectability index as a figure-of-merit. Beam-propagation simulations were used for validation and illustration of the analytical framework. Differential phase contrast improved detectability compared to absorption contrast, in particular for fine tumor structures. This result was supported by images of human mastectomy samples that were acquired with a conventional detector. The optimal incident energy was higher in differential phase contrast than in absorption contrast when disregarding the setup design energy. Further, optimal weighting of the transmitted spectrum was found to have a weaker energy dependence than for absorption contrast. Taking the design energy into account yielded a superimposed maximum on both detectability as a function of incident energy, and on optimal weighting. Spectral material decomposition was not facilitated by phase contrast, but phase information may be used instead of spectral information.

Paper Details

Date Published: 2 March 2012
PDF: 12 pages
Proc. SPIE 8313, Medical Imaging 2012: Physics of Medical Imaging, 83130F (2 March 2012); doi: 10.1117/12.910615
Show Author Affiliations
E. Fredenberg, Royal Institute of Technology (Sweden)
Philips Women's Healthcare (Sweden)
E. Roessl, Philips Technologie GmbH Innovative Technologies (Germany)
T. Koehler, Philips Technologie GmbH Innovative Technologies (Germany)
U. van Stevendaal, Philips Technologie GmbH Innovative Technologies (Germany)
I. Schulze-Wenck, Philips Healthcare (Germany)
N. Wieberneit, Philips Healthcare (Germany)
M. Stampanoni, Swiss Light Source, Paul Scherrer Institut (Switzerland)
Institute for Biomedical Engineering, University and ETH Zürich (Switzerland)
Z. Wang, Swiss Light Source, Paul Scherrer Institut (Switzerland)
R. A. Kubik-Huch, Kantonsspital Baden (Switzerland)
N. Hauser, Kantonsspital Baden (Switzerland)
M. Lundqvist, Philips Women's Healthcare (Sweden)
M. Danielsson, Royal Institute of Technology (Sweden)
Philips Women's Healthcare (United Kingdom)
M. Åslund, Philips Women's Healthcare (Sweden)

Published in SPIE Proceedings Vol. 8313:
Medical Imaging 2012: Physics of Medical Imaging
Norbert J. Pelc; Robert M. Nishikawa; Bruce R. Whiting, Editor(s)

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