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Proceedings Paper

OCT monitoring of cosmetic creams in human skin in vivo
Author(s): Seung Hee Han; Chang Han Yoon; Leigh Conroy; I. Alex Vitkin
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Paper Abstract

Optical coherence tomography (OCT) is a tool currently used for noninvasive diagnosis of human disease as well as for monitoring treatment during or after therapy. In this study, OCT was used to examine penetration and accumulation of cosmetic creams on human hand skin. The samples varied in collagen content with one formulation containing soluble collagen as its primary active ingredient. Collagen is a major connective tissue protein that is essential in maintaining health vitality and strength of many organs. The penetration and localization of collagen in cosmetic creams is thought to be the main determinant of the efficacy of new collagen synthesis. Detection and quantification of collagen in cosmetic creams applied to skin may thus help predict the eventual efficacy of the product in skin collagen regeneration. We hypothesize that the topically applied collagen may be detectable by OCT through its modulation of skin scattering properties. To test this hypothesis, we used a FDML swept-source optical coherence tomography (SS-OCT) system. A particular location on the skin of two male adult volunteers was used to investigate 4 different cosmetic creams. The duration of OCT monitoring of cosmetic penetration into skin ranged from 5 minutes to 2 hours following topical application. The results showed that OCT can discriminate between a cream with collagen and other collagen-free formulations. Thus it seems feasible that OCT intensity can monitor the in vivo effects of topical application of collagen contained in cosmetic formulations.

Paper Details

Date Published: 9 February 2012
PDF: 9 pages
Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82070W (9 February 2012); doi: 10.1117/12.909504
Show Author Affiliations
Seung Hee Han, Sogang Univ. (Korea, Republic of)
Ontario Cancer Institute (Canada)
Univ. of Toronto (Canada)
Chang Han Yoon, Sogang Univ. (Canada)
Leigh Conroy, Ontario Cancer Institute (Canada)
Univ. of Toronto (Canada)
I. Alex Vitkin, Ontario Cancer Institute (Canada)
Univ. of Toronto (Canada)

Published in SPIE Proceedings Vol. 8207:
Photonic Therapeutics and Diagnostics VIII
Anita Mahadevan-Jansen; Andreas Mandelis; Kenton W. Gregory M.D.; Nikiforos Kollias; Hyun Wook Kang; Henry Hirschberg M.D.; Melissa J. Suter; Brian Jet-Fei Wong M.D.; Justus F. Ilgner M.D.; Stephen Lam; Bodo E. Knudsen M.D.; Steen Madsen; E. Duco Jansen; Bernard Choi; Guillermo J. Tearney M.D.; Laura Marcu; Haishan Zeng; Matthew Brenner; Krzysztof Izdebski, Editor(s)

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