Share Email Print

Proceedings Paper

Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

A side-viewing, 2 mm diameter, surface magnifying chromoendoscopy (SMC)-optical coherence tomography (OCT) endoscope has been designed for simultaneous, non-destructive surface fluorescence visualization and cross-sectional imaging. We apply this endoscope to in vivo examination of mouse colon. A 30,000 element fiber bundle is combined with single mode fibers. The distal optics consist of a gradient-index lens and spacer to provide a magnification of 1 at a working distance of 1.58 mm in air, necessary to image the sample through a 0.23 mm thick outer glass envelope, and an aluminized right-angle prism fixed to the distal end of the GRIN lens assembly. The resulting 1:1 imaging system is capable of 3.9 μm lateral and 2.3 μm axial resolution in the OCT channel, and 125 lp/mm resolution across a 0.70 mm field of view in the SMC channel. The endoscope can perform high contrast crypt visualization, molecular imaging, and cross-sectional imaging of colon microstructure.

Paper Details

Date Published: 1 March 2012
PDF: 9 pages
Proc. SPIE 8217, Endoscopic Microscopy VII, 821703 (1 March 2012); doi: 10.1117/12.909291
Show Author Affiliations
R. Andrew Wall, The Univ. of Arizona (United States)
Jennifer K. Barton, The Univ. of Arizona (United States)

Published in SPIE Proceedings Vol. 8217:
Endoscopic Microscopy VII
Guillermo J. Tearney; Thomas D. Wang M.D., Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?