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Proceedings Paper

Feasibility and methodology of optical coherence tomography imaging of human intracranial aneurysms: ex vivo pilot study
Author(s): Barry Vuong; Cuiru Sun; Tim-Rasmus Khiel; Joseph A. Gardecki; Beau A. Standish; Leodante da Costa; Josaphat de Morais; Guillermo J. Tearney; Victor X. D. Yang
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Paper Abstract

Rupture of intracranial aneurysm is a common cause of subarachnoid hemorrhage. An aneurysm may undergo microscopic morphological changes or remodeling of the vessel wall prior to rupture, which could potentially be imaged. In this study we present methods of tissue sample preparation of intracranial aneurysms and correlation between optical coherence tomography imaging and routine histology. OCT has a potential future in the assessment of microscopic features of aneurysms, which may correlate to the risk of rupture.

Paper Details

Date Published: 17 February 2012
PDF: 8 pages
Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82074M (17 February 2012); doi: 10.1117/12.908998
Show Author Affiliations
Barry Vuong, Ryerson Univ. (Canada)
Cuiru Sun, Ryerson Univ. (Canada)
Tim-Rasmus Khiel, Univ. Health Network (Canada)
Joseph A. Gardecki, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Harvard Medical School (United States)
Beau A. Standish, Ryerson Univ. (Canada)
Leodante da Costa, Sunnybrook Health Sciences Ctr. (Canada)
Univ. of Toronto (Canada)
Josaphat de Morais, Hospital de Baleia (Brazil)
Guillermo J. Tearney, Wellman Ctr. for Photomedicine, Massachusetts General Hospital (United States)
Harvard-MIT Health Sciences and Technology (United States)
Victor X. D. Yang, Ryerson Univ. (Canada)
Univ. of Toronto (Canada)

Published in SPIE Proceedings Vol. 8207:
Photonic Therapeutics and Diagnostics VIII
Anita Mahadevan-Jansen; Andreas Mandelis; Kenton W. Gregory M.D.; Nikiforos Kollias; Hyun Wook Kang; Henry Hirschberg M.D.; Melissa J. Suter; Brian Jet-Fei Wong M.D.; Justus F. Ilgner M.D.; Stephen Lam; Bodo E. Knudsen M.D.; Steen Madsen; E. Duco Jansen; Bernard Choi; Guillermo J. Tearney M.D.; Laura Marcu; Haishan Zeng; Matthew Brenner; Krzysztof Izdebski, Editor(s)

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