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Proceedings Paper

In vivo measurement of differential motion inside the organ of Corti using a low coherence interferometer system
Author(s): Fangyi Chen; Dingjun Zha; Anders Fridberger; Jiefu Zheng; Niloy Choudhury; Steven L. Jacques; Ruikang K. Wang; Alfred L. Nuttall
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Paper Abstract

The differential motion of the organ of Corti has been expected as a result of the outer hair cell force, believed to be necessary for the cochlear amplifier. In vitro experiments have been performed to demonstrate this motion but the in vivo data was unavailable due to the technical difficulties. Using a specially-designed time-domain optical coherence tomography system, we performed in vivo imaging and vibration measurement at the sensitive base of the guinea pig cochlea. This technique, for the first time, provides in vivo information about the internal vibration of the organ of Corti. At low sound level, when the cochlea is more sensitive, top surface of the organ of Corti, the reticular lamina (RL) showed tuning at a higher frequency than of the bottom surface, basilar membrane (BM) and its vibration amplitude is 2-3 times of that of the BM. Corresponding to the frequency difference, the phase of RL vibration is lead to that of the BM. Both the amplitude gain and the phase lead on RL is level dependent. This suggests that they are related to the cochlear amplification. The amplitude gain at the RL is an enhancement of the BM motion for stimulating the stereocillia. The advance in time of RL vibration can prepare proper timing of stereocillia stimulation for the cochlear amplification.

Paper Details

Date Published: 9 February 2012
PDF: 3 pages
Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 820726 (9 February 2012); doi: 10.1117/12.908933
Show Author Affiliations
Fangyi Chen, Oregon Health & Science Univ. (United States)
Dingjun Zha, Oregon Health & Science Univ. (United States)
Anders Fridberger, Karolinska Institutet (Sweden)
Jiefu Zheng, Oregon Health & Science Univ. (United States)
Niloy Choudhury, Oregon Health & Science Univ. (United States)
Steven L. Jacques, Oregon Health & Science Univ. (United States)
Ruikang K. Wang, Univ. of Washington (United States)
Alfred L. Nuttall, Oregon Health & Science Univ. (United States)

Published in SPIE Proceedings Vol. 8207:
Photonic Therapeutics and Diagnostics VIII
Anita Mahadevan-Jansen; Andreas Mandelis; Kenton W. Gregory M.D.; Nikiforos Kollias; Hyun Wook Kang; Henry Hirschberg M.D.; Melissa J. Suter; Brian Jet-Fei Wong M.D.; Justus F. Ilgner M.D.; Stephen Lam; Bodo E. Knudsen M.D.; Steen Madsen; E. Duco Jansen; Bernard Choi; Guillermo J. Tearney M.D.; Laura Marcu; Haishan Zeng; Matthew Brenner; Krzysztof Izdebski, Editor(s)

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