Multiphoton imaging methods are excellent for non-invasive imaging of living tissue without any need of additional contrast agents. The increasing demand for endoscopic techniques has forced the development of multiphoton endoscopes for imaging of areas with reduced accessibility like chronic wounds. Gradient index (GRIN) lenses can miniaturize the bulky distal focusing optics of conventional tomographs to a diameter of less than 1.4 mm and a numerical aperture (NA) of 0.8. We combined a high NA clinical multiphoton endoscope with existing multiphoton tomographs like the DermaInspect® and the MPTflex® to enable the examination of wound healing processes.

Date Published: 2 March 2012
PDF: 8 pages
Proc. SPIE 8217, Endoscopic Microscopy VII, 821706 (2 March 2012); doi: 10.1117/12.908755

Published in SPIE Proceedings Vol. 8217:
Endoscopic Microscopy VII
Guillermo J. Tearney; Thomas D. Wang M.D., Editor(s)