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Proceedings Paper

Label-free DNA biosensor based on doubled tilted fiber Bragg grating
Author(s): Alessandro Candiani; Michele Sozzi; Annamaria Cucinotta; Stefano Selleri; Rosanna Veneziano; Roberto Corradini; Rosangela Marchelli; Paul Childs; Stavros Pissadakis
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Paper Abstract

The realization of a DNA biosensor based on Double Tilted Fiber Bragg Grating (DTFBG) for label-free detection has been demonstrated. To our knowledge this is the first time that a biosensor has been realized with such kind of device. The surface of the optical fiber has been functionalized with peptide nucleic acid (PNA) in order to capture DNA strands. The changes of the interference fringes visibility of the grating, due to the PNA-DNA binding, proved the occurred fiber hybridization. The re-use of the fiber for multiple measurements and the selectivity of the sensor have been also investigated.

Paper Details

Date Published: 30 January 2012
PDF: 8 pages
Proc. SPIE 8218, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XII, 82180N (30 January 2012); doi: 10.1117/12.908100
Show Author Affiliations
Alessandro Candiani, Univ. of Parma (Italy)
Michele Sozzi, Univ. of Parma (Italy)
Annamaria Cucinotta, Univ. of Parma (Italy)
Stefano Selleri, Univ. of Parma (Italy)
Rosanna Veneziano, Univ. of Parma (Italy)
Roberto Corradini, Univ. of Parma (Italy)
Rosangela Marchelli, Univ. of Parma (Italy)
Paul Childs, Foundation for Research and Technology-Hellas (Greece)
Stavros Pissadakis, Foundation for Research and Technology-Hellas (Greece)

Published in SPIE Proceedings Vol. 8218:
Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XII
Israel Gannot, Editor(s)

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