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Proceedings Paper

Imaging breast lesions using the Twente photoacoustic mammoscope: ongoing clinical experience
Author(s): M. Heijblom; D. Piras; W. Xia; J. C. G. van Hespen; F. M. van den Engh; J. M. Klaase; T. G. van Leeuwen; W. Steenbergen; S. Manohar
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Paper Abstract

Current imaging modalities are often not able to detect early stages of breast cancer with high imaging contrast. Visualizing malignancy-associated increased hemoglobin concentrations might improve breast cancer diagnosis. Photoacoustic imaging can visualize hemoglobin in tissue with optical contrast and ultrasound resolution, which makes it potentially ideal for breast imaging. The Twente Photoacoustic Mammoscope (PAM) has been designed specifically for this purpose. Based on a successful pilot study in 2007, a large clinical study using PAM has been started in December 2010. PAM uses a pulsed Q-switched Nd:YAG laser at 1064 nm to illuminate a region of interest on the breast. Photoacoustic signals are detected with a 1MHz, unfocused ultrasound detector array. Three dimensional data are reconstructed using an acoustic backprojection algorithm. Those reconstructed images are compared with conventional imaging and histopathology. In the first phase of the study, the goal was to optimize the visualization of malignancies. We performed sixteen technically acceptable measurements on confined breast malignancies. In the reconstructed volumes of all malignancies, a confined high contrast region could be identified at the expected lesion depth. After ten successful measurements, the illumination area was increased and the fluence was substantially decreased. This caused a further significant increase in PAM lesion contrast.

Paper Details

Date Published: 23 February 2012
PDF: 10 pages
Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82230C (23 February 2012); doi: 10.1117/12.908072
Show Author Affiliations
M. Heijblom, Univ. of Twente (Netherlands)
Medisch Spectrum Twente Hospital (Netherlands)
D. Piras, Univ. of Twente (Netherlands)
W. Xia, Univ. of Twente (Netherlands)
J. C. G. van Hespen, Univ. of Twente (Netherlands)
F. M. van den Engh, Medisch Spectrum Twente (Netherlands)
J. M. Klaase, Medisch Spectrum Twente (Netherlands)
T. G. van Leeuwen, Univ. of Twente (Netherlands)
Academic Medical Ctr., Univ. Amsterdam (Netherlands)
W. Steenbergen, Univ. of Twente (Netherlands)
S. Manohar, Univ. of Twente (Netherlands)

Published in SPIE Proceedings Vol. 8223:
Photons Plus Ultrasound: Imaging and Sensing 2012
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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