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Proceedings Paper

Quantitative RNFL attenuation coefficient measurements by RPE-normalized OCT data
Author(s): K. A. Vermeer; J. van der Schoot; H. G. Lemij; J. F. de Boer
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Paper Abstract

We demonstrate significantly different scattering coefficients of the retinal nerve fiber layer (RNFL) between normal and glaucoma subjects. In clinical care, SD-OCT is routinely used to assess the RNFL thickness for glaucoma management. In this way, the full OCT data set is conveniently reduced to an easy to interpret output, matching results from older (non- OCT) instruments. However, OCT provides more data, such as the signal strength itself, which is due to backscattering in the retinal layers. For quantitative analysis, this signal should be normalized to adjust for local differences in the intensity of the beam that reaches the retina. In this paper, we introduce a model that relates the OCT signal to the attenuation coefficient of the tissue. The average RNFL signal (within an A-line) was then normalized based on the observed RPE signal, resulting in normalized RNFL attenuation coefficient maps. These maps showed local defects matching those found in thickness data. The average (normalized) RNFL attenuation coefficient of a fixed band around the optic nerve head was significantly lower in glaucomatous eyes than in normal eyes (3.0mm-1 vs. 4.9mm-1, P<0.01, Mann-Whitney test).

Paper Details

Date Published: 9 March 2012
PDF: 6 pages
Proc. SPIE 8209, Ophthalmic Technologies XXII, 82090U (9 March 2012); doi: 10.1117/12.907764
Show Author Affiliations
K. A. Vermeer, Rotterdam Eye Hospital (Netherlands)
Rotterdam Ophthalmic Institute (Netherlands)
J. van der Schoot, Rotterdam Eye Hospital (Netherlands)
Rotterdam Ophthalmic Institute (Netherlands)
H. G. Lemij, Rotterdam Eye Hospital (Netherlands)
Rotterdam Ophthalmic Institute (Netherlands)
J. F. de Boer, Rotterdam Eye Hospital (Netherlands)
Rotterdam Ophthalmic Institute (Netherlands)
VU Univ., Amsterdam (Netherlands)

Published in SPIE Proceedings Vol. 8209:
Ophthalmic Technologies XXII
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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