Proceedings Paper
Development of a widefield SERS imaging endoscope| Format | Member Price | Non-Member Price |
|---|---|---|
| $17.00 | $21.00 |
Paper Abstract
We report on the design and testing of a prototype widefield surface enhanced Raman scattering (SERS) imaging system
based on a fiber optic bronchoscope using bandpass filters for Raman signal selection. The SERS contrast agents
employed consist of gold nanoparticles encoded with a Raman-active dye and made specific for lung adenocarcinoma
tissue through the use of an anti-epidermal growth factor receptor (EGFR) antibody. By exploiting the extremely narrow
SERS spectral peaks we demonstrate a facile method of background fluorescence rejection that can be implemented at
sub-video rates. The system has been tested on in-vivo tissues and performance metrics, including the maximum tissue
penetration and minimum detectable nanoparticle quantity have been determined in a standardized fashion.
Paper Details
Date Published: 1 March 2012
PDF: 6 pages
Proc. SPIE 8217, Endoscopic Microscopy VII, 821704 (1 March 2012); doi: 10.1117/12.907304
Published in SPIE Proceedings Vol. 8217:
Endoscopic Microscopy VII
Guillermo J. Tearney; Thomas D. Wang M.D., Editor(s)
PDF: 6 pages
Proc. SPIE 8217, Endoscopic Microscopy VII, 821704 (1 March 2012); doi: 10.1117/12.907304
Show Author Affiliations
Patrick Z. McVeigh, Univ. of Toronto (Canada)
Rupananda J. Mallia, Ontario Cancer Institute, Univ. Health Network (Canada)
Rupananda J. Mallia, Ontario Cancer Institute, Univ. Health Network (Canada)
Israel Veilleux, Ontario Cancer Institute, Univ. Health Network (Canada)
Brian C. Wilson, Univ. of Toronto (Canada)
Ontario Cancer Institute, Univ. Health Network (Canada)
Brian C. Wilson, Univ. of Toronto (Canada)
Ontario Cancer Institute, Univ. Health Network (Canada)
Published in SPIE Proceedings Vol. 8217:
Endoscopic Microscopy VII
Guillermo J. Tearney; Thomas D. Wang M.D., Editor(s)
© SPIE. Terms of Use
