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Proceedings Paper

Development of a widefield SERS imaging endoscope
Author(s): Patrick Z. McVeigh; Rupananda J. Mallia; Israel Veilleux; Brian C. Wilson
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Paper Abstract

We report on the design and testing of a prototype widefield surface enhanced Raman scattering (SERS) imaging system based on a fiber optic bronchoscope using bandpass filters for Raman signal selection. The SERS contrast agents employed consist of gold nanoparticles encoded with a Raman-active dye and made specific for lung adenocarcinoma tissue through the use of an anti-epidermal growth factor receptor (EGFR) antibody. By exploiting the extremely narrow SERS spectral peaks we demonstrate a facile method of background fluorescence rejection that can be implemented at sub-video rates. The system has been tested on in-vivo tissues and performance metrics, including the maximum tissue penetration and minimum detectable nanoparticle quantity have been determined in a standardized fashion.

Paper Details

Date Published: 1 March 2012
PDF: 6 pages
Proc. SPIE 8217, Endoscopic Microscopy VII, 821704 (1 March 2012); doi: 10.1117/12.907304
Show Author Affiliations
Patrick Z. McVeigh, Univ. of Toronto (Canada)
Rupananda J. Mallia, Ontario Cancer Institute, Univ. Health Network (Canada)
Israel Veilleux, Ontario Cancer Institute, Univ. Health Network (Canada)
Brian C. Wilson, Univ. of Toronto (Canada)
Ontario Cancer Institute, Univ. Health Network (Canada)

Published in SPIE Proceedings Vol. 8217:
Endoscopic Microscopy VII
Guillermo J. Tearney; Thomas D. Wang M.D., Editor(s)

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