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Proceedings Paper

Infrared surface plasmon spectroscopy and biosensing
Author(s): Victor Yashunsky; Alexander Zilbershtein; Vladislav Lirtsman; Tal Marciano; Benjamin Aroeti; Michael Golosovsky; Dan Davidov
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Paper Abstract

The cell morphology is a valuable indicator of the physical condition and general status of the cell. Here we demonstrate a methodology for noninvasive biosensing of adherent living cells. Our method is based on infrared reflection spectroscopy of living cells cultured on thin Au film. To characterize cell morphology we utilized the unique properties of the infrared surface plasmon (λ=1-3 μm) and infrared guided wave that travel inside the cell monolayer. We demonstrate that our method enables monitoring of submicron variations in cell morphology in real-time and in a labelfree manner. In addition to morphological characterization, our method allows investigation of chemical composition and molecular structure of cells through infrared absorption spectroscopy analysis.

Paper Details

Date Published: 6 February 2012
PDF: 7 pages
Proc. SPIE 8234, Plasmonics in Biology and Medicine IX, 823419 (6 February 2012); doi: 10.1117/12.907255
Show Author Affiliations
Victor Yashunsky, The Hebrew Univ. of Jerusalem (Israel)
Alexander Zilbershtein, The Hebrew Univ. of Jerusalem (Israel)
Vladislav Lirtsman, The Hebrew Univ. of Jerusalem (Israel)
Tal Marciano, The Hebrew Univ. of Jerusalem (Israel)
Benjamin Aroeti, The Hebrew Univ. of Jerusalem (Israel)
Michael Golosovsky, The Hebrew Univ. of Jerusalem (Israel)
Dan Davidov, The Hebrew Univ. of Jerusalem (Israel)

Published in SPIE Proceedings Vol. 8234:
Plasmonics in Biology and Medicine IX
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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