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Proceedings Paper

An intraoperative probe combining positron detection and OCT imaging for ovarian cancer detection and characterization
Author(s): Yi Yang; Tianheng Wang; Nrusingh Biswal; Patrick Kumavor; Xiaohong Wang; Mozafareddin Karimeddini; John Vento; Melinda Sanders; Molly Brewer; Quing Zhu
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Paper Abstract

In this paper, we report an intraoperative approach by combining optical coherence tomography (OCT) and position detection to detect and characterize ovarian cancers. A total of 18 ovaries were studied ex vivo. Based on histopathology result, they were classified into normal and malignant groups, respectively. On average positron count rate of 8.0-fold higher was found between malignant and normal ovaries. OCT imaging of ovaries revealed many detailed morphologic features that could be potentially valuable for detecting early malignant changes in ovarian tissue. Optical scattering coefficients of these ovaries were estimated from OCT A-lines. Normal ovarian tissue showed higher scattering coefficient than that of malignant ovarian tissue. Using a threshold of 2.00 mm-1 for all ovaries, a sensitivity of 100% and a specificity of 100% were achieved. This initial data shows our intraoperative probe based on OCT and positron detection has a great potential for ovarian cancer detection and characterization.

Paper Details

Date Published: 1 February 2012
PDF: 6 pages
Proc. SPIE 8220, Optical Biopsy X, 82200E (1 February 2012); doi: 10.1117/12.907023
Show Author Affiliations
Yi Yang, Univ. of Connecticut (United States)
Tianheng Wang, Univ. of Connecticut (United States)
Nrusingh Biswal, Univ. of Connecticut (United States)
Patrick Kumavor, Univ. of Connecticut (United States)
Xiaohong Wang, Univ. of Connecticut Health Ctr. (United States)
Mozafareddin Karimeddini, Univ. of Connecticut Health Ctr. (United States)
John Vento, Univ. of Connecticut Health Ctr. (United States)
Melinda Sanders, Univ. of Connecticut Health Ctr. (United States)
Molly Brewer
Quing Zhu, Univ. of Connecticut (United States)

Published in SPIE Proceedings Vol. 8220:
Optical Biopsy X
Robert R. Alfano; Stavros G. Demos, Editor(s)

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