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Proceedings Paper

Tailoring biocompatible Fe3O4 nanoparticles for applications to magnetic hyperthermia
Author(s): Maite Insausti; Javier Salado; Idoia Castellanos; Luis Lezama; Izaskun Gil de Muro; Jesús M. de la Fuente; Eneko Garayo; Fernando Plazaola; Teófilo Rojo
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Paper Abstract

Magnetite based nanoparticles functionalized with different ligands have been obtained by optimization of two synthetic methods. Gold surrounded Fe3O4 nanoparticles capped with oleic acid and oleylamine were achieved by thermal decomposition of metallo-organic precursors. By this way nanoparticles with perfectly defined size within 3.5 nm to 7 nm in diameter and organic content from 16.1% to 40.9 % were obtained. Precipitation of iron(II) chloride in basic solution yield magnetite nanoparticles between 20 and 40 nm with contents of organic ligands of 3 - 12 %. The samples have been characterized by X-ray diffraction, transmission electron microscopy and thermogravimetric measurements. A complete magnetic study has been performed by means of a SQUID magnetometer and electron magnetic resonance (EMR), showing the influence of capping covering on the superparamagnetic behaviour. The citotoxicity and interaction with HeLa cells was evaluated for some of the preparations. Finally, the specific absorption rate (SAR) was calculated to compare the efficiency of heating each sample for the various applied magnetic fields.

Paper Details

Date Published: 2 February 2012
PDF: 8 pages
Proc. SPIE 8232, Colloidal Nanocrystals for Biomedical Applications VII, 823210 (2 February 2012); doi: 10.1117/12.906759
Show Author Affiliations
Maite Insausti, Univ. del País Vasco (Spain)
Javier Salado, Univ. del País Vasco (Spain)
Idoia Castellanos, Univ. del País Vasco (Spain)
Luis Lezama, Univ. del País Vasco (Spain)
Izaskun Gil de Muro, Univ. del País Vasco (Spain)
Jesús M. de la Fuente, Univ. of Zaragoza (Spain)
Eneko Garayo, Univ. del País Vasco (Spain)
Fernando Plazaola, Univ. del País Vasco (Spain)
Teófilo Rojo, Univ. del País Vasco (Spain)

Published in SPIE Proceedings Vol. 8232:
Colloidal Nanocrystals for Biomedical Applications VII
Wolfgang J. Parak; Kenji Yamamoto M.D.; Marek Osinski, Editor(s)

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