Share Email Print
cover

Proceedings Paper

Drug delivery monitoring by photoacoustic tomography with an ICG encapsulated double emulsion
Author(s): Xueding Wang; Justin R. Rajian; Mario L. Fabiilli; J. Brian Fowlkes; Paul L. Carson
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

We successfully encapsulated ICG in an ultrasound-triggerable perfluorocarbon double emulsion that prevents ICG from binding with plasma proteins. Photoacoustic spectral measurements on point target as well as 2-D photoacoustic images of blood vessels revealed that the photoacoustic spectrum changes significantly in blood when the ICG-loaded emulsion undergoes acoustic droplet vaporization (ADV), which is the conversion of liquid droplets into gas bubbles using ultrasound. Other than providing a new photoacoustic contrast agent, the ICG encapsulated double emulsion, when imaged with photoacoustic tomography, could facilitate spatial and quantitative monitoring of ultrasound initiated drug delivery.

Paper Details

Date Published: 23 February 2012
PDF: 11 pages
Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82232K (23 February 2012); doi: 10.1117/12.906452
Show Author Affiliations
Xueding Wang, Univ. of Michigan Medical School (United States)
Justin R. Rajian, Univ. of Michigan Medical School (United States)
Mario L. Fabiilli, Univ. of Michigan Medical School (United States)
J. Brian Fowlkes, Univ. of Michigan Medical School (United States)
Paul L. Carson, Univ. of Michigan Medical School (United States)


Published in SPIE Proceedings Vol. 8223:
Photons Plus Ultrasound: Imaging and Sensing 2012
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

© SPIE. Terms of Use
Back to Top