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Proceedings Paper

A CT-analogous method for high-resolution fluorescence molecular tomography
Author(s): Jiao Li; Feng Gao; Qingzhen Zhu; Fenghui Li; Xin Wang; Limin Zhang; Huijuan Zhao
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Paper Abstract

In vivo biomedical imaging using near-infrared light must overcome the effects of highly light scattering, which limit the spatial resolution and affect image quality. The high-resolution, sensitive and quantitative fluorescence imaging tool is an urgent need for the applications in small-animal imaging and clinical cancer research. A CT-analogous method for fluorescence molecular tomography (FMT) on small-animal-sized models is presented to improve the spatial resolution of FMT to a limit of several millimeters, depending on the size of the tissue region to be imaged. The method combines FMT physics with the filtered back-projection scheme for image reconstruction of the fan-beam computed tomography, based on the early-photon detection of time-resolved optical signals, and is suitable for two-dimensional (2D) imaging of small size biological models. By use of a normalized Born formulation for the inversion, the algorithm is validated using full time-resolved simulated data for 2D phantom that are generated from a hybrid finite-element and finite-time-difference photon diffusion modeling, and its superiority in the improvement of the spatial resolution is demonstrated by imaging different target-to-background contrast ratios.

Paper Details

Date Published: 29 February 2012
PDF: 9 pages
Proc. SPIE 8216, Multimodal Biomedical Imaging VII, 82160W (29 February 2012); doi: 10.1117/12.905625
Show Author Affiliations
Jiao Li, Tianjin Univ. (China)
Feng Gao, Tianjin Univ. (China)
Qingzhen Zhu, Tianjin Univ. (China)
Fenghui Li, Tianjin Univ. (China)
Xin Wang, Tianjin Univ. (China)
Limin Zhang, Tianjin Univ. (China)
Huijuan Zhao, Tianjin Univ. (China)

Published in SPIE Proceedings Vol. 8216:
Multimodal Biomedical Imaging VII
Fred S. Azar; Xavier Intes, Editor(s)

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