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Proceedings Paper

A high-sensitive diffuse fluorescence tomography system with CT-analogous scanning mode
Author(s): Xin Wang; Jiao Li; Xi Yi; Linhui Wu; Wenjuan Ma; Wei Zhang; Feng Gao
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Paper Abstract

Diffuse fluorescence tomography (DFT) provides spatial distributions of fluorescence parameters by measuring fluorescence signals of probes or agents that are targeted to interior specific molecules or tissues. The potential applications of DFT can be found in drug development and early tumor diagnosis. This work proposes a CT-analogous mode of DFT, where the imaging chamber is impinged by collimated beam from a fiber-coupled laser diode and the resultant fluorescence re-emissions on the opposite side, i.e., the so-called "projections", are collected by eight detection fibers placed from 101.25º to 258.75º perspectives opposite to the incidence that are then successively filtered out into a photon-counting channel for quantification. By rotating the imaging chamber or phantom at an angular, the system acquires the "projections" of surface-emitted fluorescence under different perspectives as a CT system does. This ease of acquiring a large data-set enables realization of high-quality imaging. Pilot experiments on phantoms with Cy5.5-target embedded have validated the efficacy of the proposed method.

Paper Details

Date Published: 29 February 2012
PDF: 8 pages
Proc. SPIE 8216, Multimodal Biomedical Imaging VII, 82160V (29 February 2012); doi: 10.1117/12.905355
Show Author Affiliations
Xin Wang, Tianjin Univ. (China)
Jiao Li, Tianjin Univ. (China)
Xi Yi, Tianjin Univ. (China)
Linhui Wu, Tianjin Univ. (China)
Wenjuan Ma, Tianjin Univ. (China)
Wei Zhang, Tianjin Univ. (China)
Feng Gao, Tianjin Univ. (China)

Published in SPIE Proceedings Vol. 8216:
Multimodal Biomedical Imaging VII
Fred S. Azar; Xavier Intes, Editor(s)

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