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Proceedings Paper

Compact CdZnTe-based gamma camera for prostate cancer imaging
Author(s): Yonggang Cui; Terry Lall; Benjamin Tsui; Jianhua Yu; George Mahler; Aleksey Bolotnikov; Paul Vaska; Gianluigi De Geronimo; Paul O'Connor; George Meinken; John Joyal; John Barrett; Giuseppe Camarda; Anwar Hossain; Ki Hyun Kim; Ge Yang; Marty Pomper; Steve Cho; Ken Weisman; Youngho Seo; John Babich; Norman LaFrance; Ralph B. James
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Paper Abstract

In this paper, we discuss the design of a compact gamma camera for high-resolution prostate cancer imaging using Cadmium Zinc Telluride (CdZnTe or CZT) radiation detectors. Prostate cancer is a common disease in men. Nowadays, a blood test measuring the level of prostate specific antigen (PSA) is widely used for screening for the disease in males over 50, followed by (ultrasound) imaging-guided biopsy. However, PSA tests have a high falsepositive rate and ultrasound-guided biopsy has a high likelihood of missing small cancerous tissues. Commercial methods of nuclear medical imaging, e.g. PET and SPECT, can functionally image the organs, and potentially find cancer tissues at early stages, but their applications in diagnosing prostate cancer has been limited by the smallness of the prostate gland and the long working distance between the organ and the detectors comprising these imaging systems. CZT is a semiconductor material with wide band-gap and relatively high electron mobility, and thus can operate at room temperature without additional cooling. CZT detectors are photon-electron direct-conversion devices, thus offering high energy-resolution in detecting gamma rays, enabling energy-resolved imaging, and reducing the background of Compton-scattering events. In addition, CZT material has high stopping power for gamma rays; for medical imaging, a few-mm-thick CZT material provides adequate detection efficiency for many SPECT radiotracers. Because of these advantages, CZT detectors are becoming popular for several SPECT medical-imaging applications. Most recently, we designed a compact gamma camera using CZT detectors coupled to an application-specific-integratedcircuit (ASIC). This camera functions as a trans-rectal probe to image the prostate gland from a distance of only 1-5 cm, thus offering higher detection efficiency and higher spatial resolution. Hence, it potentially can detect prostate cancers at their early stages. The performance tests of this camera have been completed. The results show better than 6-mm resolution at a distance of 1 cm. Details of the test results are discussed in this paper.

Paper Details

Date Published: 22 August 2011
PDF: 8 pages
Proc. SPIE 8192, International Symposium on Photoelectronic Detection and Imaging 2011: Laser Sensing and Imaging; and Biological and Medical Applications of Photonics Sensing and Imaging, 819255 (22 August 2011); doi: 10.1117/12.901078
Show Author Affiliations
Yonggang Cui, Brookhaven National Lab. (United States)
Terry Lall, Hybridyne Imaging Technologies, Inc. (Canada)
Benjamin Tsui, Johns Hopkins Univ. (United States)
Jianhua Yu, Johns Hopkins Univ. (United States)
George Mahler, Brookhaven National Lab. (United States)
Aleksey Bolotnikov, Brookhaven National Lab. (United States)
Paul Vaska, Brookhaven National Lab. (United States)
Gianluigi De Geronimo, Brookhaven National Lab. (United States)
Paul O'Connor, Brookhaven National Lab. (United States)
George Meinken, Brookhaven National Lab. (United States)
John Joyal, Molecular Insight Pharmaceuticals (United States)
John Barrett, Molecular Insight Pharmaceuticals (United States)
Giuseppe Camarda, Brookhaven National Lab. (United States)
Anwar Hossain, Brookhaven National Lab. (United States)
Ki Hyun Kim, Brookhaven National Lab. (United States)
Ge Yang, Brookhaven National Lab. (United States)
Marty Pomper, Johns Hopkins Univ. (United States)
Steve Cho, Johns Hopkins Univ. (United States)
Ken Weisman, Midstate Hopital (United States)
Youngho Seo, Univ. of California at San Francisco (United States)
John Babich, Molecular Insight Pharmaceuticals (United States)
Norman LaFrance, Molecular Insight Pharmaceuticals (United States)
Ralph B. James, Brookhaven National Lab. (United States)

Published in SPIE Proceedings Vol. 8192:
International Symposium on Photoelectronic Detection and Imaging 2011: Laser Sensing and Imaging; and Biological and Medical Applications of Photonics Sensing and Imaging
Farzin Amzajerdian; Weibiao Chen; Chunqing Gao; Tianyu Xie, Editor(s)

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