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Proceedings Paper

Digital holography and tissue dynamics spectroscopy: on the road to high-content drug discovery
Author(s): D. D. Nolte; R. An; K. Jeong; J. Turek
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Paper Abstract

Digital holography, Fourier optics and speckle are combined to enable a new direction in drug discovery. Optical coherence imaging (OCI) is a coherence-gated imaging approach that captures dynamic speckle from inside living tissue. The speckle temporal fluctuations arise from internal motions in the biological tissue, and the changes in these motions caused by applying drugs can be captured and quantified using tissue dynamics spectroscopy (TDS). A phenotypic profile of many reference drugs provides a training set that would help classify new compounds that may be candidates as new anti-cancer drugs.

Paper Details

Date Published: 20 September 2011
PDF: 7 pages
Proc. SPIE 8122, Tribute to Joseph W. Goodman, 81220N (20 September 2011); doi: 10.1117/12.896618
Show Author Affiliations
D. D. Nolte, Purdue Univ. (United States)
R. An, Purdue Univ. (United States)
K. Jeong, Purdue Univ. (United States)
Korea Military Academy (Korea, Republic of)
J. Turek, Purdue Univ. (United States)

Published in SPIE Proceedings Vol. 8122:
Tribute to Joseph W. Goodman
H. John Caulfield; Henri H. Arsenault, Editor(s)

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