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Proceedings Paper

Diverse nucleotide compositions and sequence fluctuation in Rubisco protein genes
Author(s): Todd Holden; S. Dehipawala; E. Cheung; R. Bienaime; J. Ye; G. Tremberger Jr.; P. Schneider; D. Lieberman; T. Cheung
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Paper Abstract

The Rubisco protein-enzyme is arguably the most abundance protein on Earth. The biology dogma of transcription and translation necessitates the study of the Rubisco genes and Rubisco-like genes in various species. Stronger correlation of fractal dimension of the atomic number fluctuation along a DNA sequence with Shannon entropy has been observed in the studied Rubisco-like gene sequences, suggesting a more diverse evolutionary pressure and constraints in the Rubisco sequences. The strategy of using metal for structural stabilization appears to be an ancient mechanism, with data from the porphobilinogen deaminase gene in Capsaspora owczarzaki and Monosiga brevicollis. Using the chi-square distance probability, our analysis supports the conjecture that the more ancient Rubisco-like sequence in Microcystis aeruginosa would have experienced very different evolutionary pressure and bio-chemical constraint as compared to Bordetella bronchiseptica, the two microbes occupying either end of the correlation graph. Our exploratory study would indicate that high fractal dimension Rubisco sequence would support high carbon dioxide rate via the Michaelis- Menten coefficient; with implication for the control of the whooping cough pathogen Bordetella bronchiseptica, a microbe containing a high fractal dimension Rubisco-like sequence (2.07). Using the internal comparison of chi-square distance probability for 16S rRNA (~ E-22) versus radiation repair Rec-A gene (~ E-05) in high GC content Deinococcus radiodurans, our analysis supports the conjecture that high GC content microbes containing Rubisco-like sequence are likely to include an extra-terrestrial origin, relative to Deinococcus radiodurans. Similar photosynthesis process that could utilize host star radiation would not compete with radiation resistant process from the biology dogma perspective in environments such as Mars and exoplanets.

Paper Details

Date Published: 23 September 2011
PDF: 11 pages
Proc. SPIE 8152, Instruments, Methods, and Missions for Astrobiology XIV, 81520S (23 September 2011); doi: 10.1117/12.893434
Show Author Affiliations
Todd Holden, Queensborough Community College of CUNY (United States)
S. Dehipawala, Queensborough Community College of CUNY (United States)
E. Cheung, Queensborough Community College of CUNY (United States)
R. Bienaime, Queensborough Community College of CUNY (United States)
J. Ye, Queensborough Community College of CUNY (United States)
G. Tremberger Jr., Queensborough Community College of CUNY (United States)
P. Schneider, Queensborough Community College of CUNY (United States)
D. Lieberman, Queensborough Community College of CUNY (United States)
T. Cheung, Queensborough Community College of CUNY (United States)


Published in SPIE Proceedings Vol. 8152:
Instruments, Methods, and Missions for Astrobiology XIV
Richard B. Hoover; Paul C. W. Davies; Gilbert V. Levin; Alexei Yu. Rozanov, Editor(s)

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