
Proceedings Paper
Practical pathology perspectives for minimally invasive hyperthermic medical devicesFormat | Member Price | Non-Member Price |
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Paper Abstract
Currently, hyperthermic-based minimally invasive medical devices are available for the treatment of
dysfunctional and neoplastic tissues in a variety of organ systems. These therapies employ a spectrum of
modalities for delivering heat energy to the targeted tissue, including radiofrequency/microwave, high
intensity focused ultrasound, conductive/convective sources and others. While differences in energy
transfer and organ systems exist, hyperthermic treatment sites show a spectrum of changes that intimately
correlate with the thermal history generated in the tissue (temperature-time dependence). As a result, these
hyperthermic medical technologies can be viewed using a "gradient" approach. First, the thermal
applications themselves can be globally categorized along a high-dose ablation to low-dose ablation to lowdose
non-ablative rejuvenating slope. Second, the resultant tissue changes can be viewed along a
decreasing thermal dose gradient from thermally/heat-fixed tissue necrosis to coagulative tissue necrosis to
partial tissue necrosis (transition zone) to subtle non-necrotizing tissue changes. Finally, a gradient of
cellular and structural protein denaturation is present, especially within the transition zone and adjacent
viable tissue region. A hyperthermic treatment's location along these gradients depends more on the overall
thermal history it generates than the amount of energy it deposits into the tissue. The features of these
gradients are highlighted to provide a better understanding of hyperthermic device associated tissue
changes and their associated healing responses.
Paper Details
Date Published: 23 February 2011
PDF: 12 pages
Proc. SPIE 7901, Energy-based Treatment of Tissue and Assessment VI, 790103 (23 February 2011); doi: 10.1117/12.892498
Published in SPIE Proceedings Vol. 7901:
Energy-based Treatment of Tissue and Assessment VI
Thomas P. Ryan, Editor(s)
PDF: 12 pages
Proc. SPIE 7901, Energy-based Treatment of Tissue and Assessment VI, 790103 (23 February 2011); doi: 10.1117/12.892498
Show Author Affiliations
James E. Coad, West Virginia Univ. (United States)
Published in SPIE Proceedings Vol. 7901:
Energy-based Treatment of Tissue and Assessment VI
Thomas P. Ryan, Editor(s)
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