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Proceedings Paper

Development of a multi-view multi-spectral bioluminescence tomography small animal imaging system
Author(s): James A. Guggenheim; Hamid Dehghani; Hector Basevi; Iain B. Styles; Jon Frampton
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Paper Abstract

Steps are presented towards the development of a new bioluminescence tomography (BLT) imaging system for in vivo small animal studies. A 2-mirror-based multi-view data collection scheme is investigated in conjunction with multi-spectral imaging, leading to the production of 3D volumetric maps of molecular source distributions in simulation and in physical phantom studies by way of a finite element model (FEM) based reconstruction method. A proof of concept is subsequently demonstrated showing a full work flow from data acquisition to 3D reconstruction. Results suggest that the multi-view mirror-based approach represents a strong improvement over standard single-view methods, with improvements of up to 58% in source localisation accuracy being observed for deep sources.

Paper Details

Date Published: 14 June 2011
PDF: 12 pages
Proc. SPIE 8088, Diffuse Optical Imaging III, 80881K (14 June 2011); doi: 10.1117/12.889863
Show Author Affiliations
James A. Guggenheim, The Univ. of Birmingham (United Kingdom)
Hamid Dehghani, The Univ. of Birmingham (United Kingdom)
Hector Basevi, The Univ. of Birmingham (United Kingdom)
Iain B. Styles, The Univ. of Birmingham (United Kingdom)
Jon Frampton, The Univ. of Birmingham (United Kingdom)

Published in SPIE Proceedings Vol. 8088:
Diffuse Optical Imaging III
Andreas H. Hielscher; Paola Taroni, Editor(s)

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