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Proceedings Paper

Optoacoustic tomography in preclinical research: in vivo distribution of highly purified PEG-coated gold nanorods
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Paper Abstract

We report on the optoacoustic (OA) imaging of the whole mouse body using a biocompatible contrast agent - highly purified, pegylated gold nanorods (GNR) - which has strong optical absorption in the near-infrared region and low level of toxicity. In vitro toxicity studies showed no significant change in survival rates of the cultured normal epithelium IEC-6 cells when incubated for 24 hours with up to 1 nM of GNR. In vivo toxicity studies in nude mice showed no pathological changes in liver 1 month after the IV injection of GNR with intra-body concentration around 0.25-0.50 nM. In order to study the enhancement of the OA contrast and accumulation of GNR in different tissues, we performed 3D OA imaging of live nude mice with IV-injected GNR. The enhancement of the OA contrast in comparison with the images of the untreated mice was visible starting 1 hour after the GNR injection. The OA contrast of kidneys, liver, and spleen peaked at about 2-3 days after the administration of the GNR, and then was gradually reducing.

Paper Details

Date Published: 14 June 2011
PDF: 7 pages
Proc. SPIE 8089, Molecular Imaging III, 808902 (14 June 2011); doi: 10.1117/12.889757
Show Author Affiliations
Richard Su, TomoWave Labs., Inc. (United States)
Univ. of Houston (United States)
Anton Liopo, TomoWave Labs., Inc. (United States)
Hans-Peter Brecht, TomoWave Labs., Inc. (United States)
Sergey Ermilov, TomoWave Labs., Inc. (United States)
Kirill Larin, Univ. of Houston (United States)
Alexander A. Oraevsky, TomoWave Labs., Inc. (United States)
Univ. of Houston (United States)

Published in SPIE Proceedings Vol. 8089:
Molecular Imaging III
Charles P. Lin; Vasilis Ntziachristos, Editor(s)

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