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Proceedings Paper

A model-based comparison of implicit and direct dosimetry for ALA-PDT of skin
Author(s): Baochang Liu; Thomas J. Farrell; Michael S. Patterson
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Paper Abstract

Photosensitizer fluorescence photobleaching and Singlet Oxygen (1O2) Luminescence Dosimetry (SOLD) are being studied as potential dosimetric tools for ALA-PDT of skin diseases. However, the correlation of both SOLD data and PpIX fluorescence to 1O2 distribution is difficult to interpret because of the temporal and spatial variations of the PDT parameters (light fluence rate, photosensitizer concentration and oxygen concentration). This work used our dynamic model to investigate both dosimetry approaches for varied PpIX concentration and distribution, and three commonly used treatment wavelengths. The results show that SOLD is much less dependent upon the treatment parameters, which implies it has better potential as a "gold standard" dosimetric tool for clinical PDT.

Paper Details

Date Published: 2 June 2011
PDF: 6 pages
Proc. SPIE 8092, Medical Laser Applications and Laser-Tissue Interactions V, 80920H (2 June 2011); doi: 10.1117/12.889746
Show Author Affiliations
Baochang Liu, McMaster Univ. (Canada)
Juravinski Cancer Ctr. (Canada)
Thomas J. Farrell, McMaster Univ. (Canada)
Juravinski Cancer Ctr. (Canada)
Michael S. Patterson, McMaster Univ. (Canada)
Juravinski Cancer Ctr. (Canada)

Published in SPIE Proceedings Vol. 8092:
Medical Laser Applications and Laser-Tissue Interactions V
Ronald Sroka; Lothar D. Lilge, Editor(s)

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