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Proceedings Paper

Optical coherence tomography for imaging of subpleural alveolar structure using a Fourier domain mode locked laser
Author(s): Lars Kirsten; Julia Walther; Peter Cimalla; Maria Gaertner; Sven Meissner; Edmund Koch
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Paper Abstract

Optical coherence tomography (OCT) is a noninvasive imaging modality generating cross sectional and volumetric images of translucent samples. In Fourier domain OCT (FD OCT), the depth profile is calculated by a fast Fourier transformation of the interference spectrum, providing speed and SNR advantage and thus making FD OCT well suitable in biomedical applications. The interference spectrum can be acquired spectrally resolved in spectral domain OCT or time-resolved in optical frequency domain imaging (OFDI). Since OCT images still suffer from motion artifacts, especially under in vivo conditions, increased depth scan rates are required. Therefor, the principle of Fourier domain mode locking has been presented by R. Huber et al. circumventing the speed limitations of conventional FD OCT systems. In FDML lasers, a long single mode fiber is inserted in the ring resonator of the laser resulting in an optical round trip time of a few microseconds. Sweeping the wavelength synchronously by a tunable Fabry-Perot filter can provide wavelength sweeps with repetition rates up to a few MHz used for OFDI. Imaging of subpleural lung tissue for investigation of lung dynamics and its elastic properties is a further biomedical application demanding high-speed OCT imaging techniques. For the first time, the visualization of subpleural alveolar structures of a rabbit lung is presented by the use of an FDML-based OCT system enabling repetition rates of 49.5 kHz and 122.6 kHz, respectively.

Paper Details

Date Published: 1 June 2011
PDF: 6 pages
Proc. SPIE 8091, Optical Coherence Tomography and Coherence Techniques V, 809118 (1 June 2011); doi: 10.1117/12.889615
Show Author Affiliations
Lars Kirsten, Dresden Univ. of Technology (Germany)
Julia Walther, Dresden Univ. of Technology (Germany)
Peter Cimalla, Dresden Univ. of Technology (Germany)
Maria Gaertner, Dresden Univ. of Technology (Germany)
Sven Meissner, Dresden Univ. of Technology (Germany)
Edmund Koch, Dresden Univ. of Technology (Germany)

Published in SPIE Proceedings Vol. 8091:
Optical Coherence Tomography and Coherence Techniques V
Rainer A. Leitgeb; Brett E. Bouma, Editor(s)

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