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Proceedings Paper

Toward absolute quantification in CW-FDOT systems: use of a priori information
Author(s): Anne Planat-Chrétien; Anne Koenig; Jean-Guillaume Coutard; Lionel Hervé; Marco Brambilla; Jean-Marc Dinten
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Paper Abstract

In the context of continuous wave fluorescence-enhanced diffuse optical tomography, we show that the reconstructed fluorescence depends on the local diffusion coefficient and demonstrate that the a priori knowledge of specific optical parameters may lead to the reconstruction of absolute quantification of the fluorophore distribution. In this context, we point out the potentiality of a bimodal instrument coupling functional and morphological information to provide knowledge of the distribution of optical parameters of internal organs. We show some quantitative results on simulated and experimental data on phantoms and conclude suggesting the use of optical parameters atlases to achieve an absolute quantification of fluorophore distribution in real contexts.

Paper Details

Date Published: 14 June 2011
PDF: 7 pages
Proc. SPIE 8088, Diffuse Optical Imaging III, 80880W (14 June 2011); doi: 10.1117/12.889583
Show Author Affiliations
Anne Planat-Chrétien, CEA/LETI (France)
Anne Koenig, CEA/LETI (France)
Jean-Guillaume Coutard, CEA/LETI (France)
Lionel Hervé, CEA/LETI (France)
Marco Brambilla, CEA/LETI (France)
Jean-Marc Dinten, CEA/LETI (France)

Published in SPIE Proceedings Vol. 8088:
Diffuse Optical Imaging III
Andreas H. Hielscher; Paola Taroni, Editor(s)

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