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Proceedings Paper

Gold nanoparticles for tumour detection and treatment
Author(s): L. Hartsuiker; W. Petersen; J. Jose; P. van Es; A. Lenferink; A. A. Poot; L. W. M. M. Terstappen; T. G. van Leeuwen; S. Manohar; C. Otto
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Paper Abstract

The use of nanoparticles in biomedical applications is emerging rapidly. Recent developments have led to numerous studies of noble metal nanoparticles, down to the level of single molecule detection in living cells. The application of noble metal nanoparticles in diagnostics and treatment of early stage carcinomas is the subject of many present studies. Gold nanoparticles are particularly interesting for optical biomedical applications due to their biocompatibility and moreover, their enhanced absorption cross-sections. The latter is a result of surface plasmon resonance, which can be tuned by altering the shape of the nanoparticles enabling usage of the near infrared tissue transparent optical window. This paper presents a brief overview of the variety of shapes, size and surface chemistries of the gold nanoparticles used for cancer detection and treatment, as well as their effects in different tumour models that have recently been investigated, both in vitro and in vivo.

Paper Details

Date Published: 10 June 2011
PDF: 10 pages
Proc. SPIE 8087, Clinical and Biomedical Spectroscopy and Imaging II, 80871O (10 June 2011); doi: 10.1117/12.889131
Show Author Affiliations
L. Hartsuiker, Univ. of Twente (Netherlands)
W. Petersen, Univ. of Twente (Netherlands)
J. Jose, Univ. of Twente (Netherlands)
P. van Es, Univ. of Twente (Netherlands)
A. Lenferink, Univ. of Twente (Netherlands)
A. A. Poot, Univ. of Twente (Netherlands)
L. W. M. M. Terstappen, Univ. of Twente (Netherlands)
T. G. van Leeuwen, Univ. of Twente (Netherlands)
Univ. of Amsterdam (Netherlands)
S. Manohar, Univ. of Twente (Netherlands)
C. Otto, Univ. of Twente (Netherlands)

Published in SPIE Proceedings Vol. 8087:
Clinical and Biomedical Spectroscopy and Imaging II
Nirmala Ramanujam; Jürgen Popp, Editor(s)

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