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Proceedings Paper

Pulsed radiobiology with laser-driven plasma accelerators
Author(s): Antonio Giulietti; Maria Grazia Andreassi; Carlo Greco
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Paper Abstract

Recently, a high efficiency regime of acceleration in laser plasmas has been discovered, allowing table top equipment to deliver doses of interest for radiotherapy with electron bunches of suitable kinetic energy. In view of an R&D program aimed to the realization of an innovative class of accelerators for medical uses, a radiobiological validation is needed. At the present time, the biological effects of electron bunches from the laser-driven electron accelerator are largely unknown. In radiobiology and radiotherapy, it is known that the early spatial distribution of energy deposition following ionizing radiation interactions with DNA molecule is crucial for the prediction of damages at cellular or tissue levels and during the clinical responses to this irradiation. The purpose of the present study is to evaluate the radio-biological effects obtained with electron bunches from a laser-driven electron accelerator compared with bunches coming from a IORT-dedicated medical Radio-frequency based linac's on human cells by the cytokinesis block micronucleus assay (CBMN). To this purpose a multidisciplinary team including radiotherapists, biologists, medical physicists, laser and plasma physicists is working at CNR Campus and University of Pisa. Dose on samples is delivered alternatively by the "laser-linac" operating at ILIL lab of Istituto Nazionale di Ottica and an RF-linac operating for IORT at Pisa S. Chiara Hospital. Experimental data are analyzed on the basis of suitable radiobiological models as well as with numerical simulation based on Monte Carlo codes. Possible collective effects are also considered in the case of ultrashort, ultradense bunches of ionizing radiation.

Paper Details

Date Published: 25 May 2011
PDF: 9 pages
Proc. SPIE 8079, Laser Acceleration of Electrons, Protons, and Ions; and Medical Applications of Laser-Generated Secondary Sources of Radiation and Particles, 80791J (25 May 2011); doi: 10.1117/12.888736
Show Author Affiliations
Antonio Giulietti, Istituto Nazionale di Ottica del CNR (Italy)
Maria Grazia Andreassi, Istituto di Fisiologia Clinica del CNR (Italy)
Carlo Greco, Univ. di Pisa (Italy)

Published in SPIE Proceedings Vol. 8079:
Laser Acceleration of Electrons, Protons, and Ions; and Medical Applications of Laser-Generated Secondary Sources of Radiation and Particles
Wim P. Leemans; Kenneth W. D. Ledingham; Eric Esarey; Simon M. Hooker, Editor(s)

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