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Proceedings Paper

Tunable wavelength interrogated sensor platform (TWIST) for point-of-care diagnostics of infectious diseases
Author(s): Sonia Grego; Kristin H. Gilchrist; Brian R. Stoner
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Paper Abstract

The TWIST platform is an optical evanescent wave sensor which enables a label-free immunoassay-based portable instrument. The approach is based on input grating coupler sensors serving as functionalized sensing devices. Binding of the target analyte to the receptor-coated grating is detected by wavelength interrogation in the telecom spectral range. We have demonstrated that high performance volumetric sensing can be achieved using a compact, low-cost telecom laser as light source. The system footprint including light source, detectors and digitizers is compact. The platform is amenable to multiplexed operation. We demonstrated a two-output system which enables detection of an analyte with an on-chip reference signal.

Paper Details

Date Published: 16 May 2011
PDF: 11 pages
Proc. SPIE 8029, Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring; and Biometric Technology for Human Identification VIII, 802906 (16 May 2011); doi: 10.1117/12.886880
Show Author Affiliations
Sonia Grego, RTI International (United States)
Kristin H. Gilchrist, RTI International (United States)
Brian R. Stoner, RTI International (United States)


Published in SPIE Proceedings Vol. 8029:
Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring; and Biometric Technology for Human Identification VIII
B. V. K. Vijaya Kumar; Sárka O. Southern; Kevin N. Montgomery; Salil Prabhakar; Arun A. Ross; Carl W. Taylor; Bernhard H. Weigl, Editor(s)

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