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Proceedings Paper

Optimization of monolithic columns for microfluidic devices
Author(s): Jayson V. Pagaduan; Weichun Yang; Adam T. Woolley
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Paper Abstract

Monolithic columns offer advantages as solid-phase extractors because they offer high surface area that can be tailored to a specific function, fast mass transport, and ease of fabrication. Porous glycidyl methacrylate-ethylene glycol dimethacrylate monoliths were polymerized in-situ in microfluidic devices, without pre-treatment of the poly(methyl methacrylate) channel surface. Cyclohexanol, 1-dodecanol and Tween 20 were used to control the pore size of the monoliths. The epoxy groups on the monolith surface can be utilized to immobilize target-specific probes such as antibodies, aptamers, or DNA for biomarker detection. Microfluidic devices integrated with solid-phase extractors should be useful for point-of-care diagnostics in detecting specific biomarkers from complex biological fluids.

Paper Details

Date Published: 13 May 2011
PDF: 7 pages
Proc. SPIE 8031, Micro- and Nanotechnology Sensors, Systems, and Applications III, 80311V (13 May 2011); doi: 10.1117/12.884265
Show Author Affiliations
Jayson V. Pagaduan, Brigham Young Univ. Provo (United States)
Weichun Yang, Brigham Young Univ. Provo (United States)
Adam T. Woolley, Brigham Young Univ. Provo (United States)

Published in SPIE Proceedings Vol. 8031:
Micro- and Nanotechnology Sensors, Systems, and Applications III
Thomas George; M. Saif Islam; Achyut K. Dutta, Editor(s)

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