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Proceedings Paper

Quantum dots as a FRET donor and nanoscaffold for multivalent DNA photonic wires
Author(s): Kelly Boeneman; Duane E. Prasuhn; Juan B. Blanco-Canosa; Philip E. Dawson; Joseph S. Melinger; Mario Ancona; Michael H. Stewart; Kimihiro Susumu; Alan Huston; Igor L. Medintz
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Paper Abstract

We demonstrate Förster resonance energy transfer (FRET) through DNA photonic wires self-assembled around a central CdSe/ZnS semiconductor quantum dot (QD). The central QD acts as a nanoscaffold and FRET donor to a series of acceptor dyes along a DNA strand. By utilizing a DNA intercalating dye, altering the location of the dyes and using a series of increasingly red-shifted dyes along the DNA, we are able to track the efficiency of energy transfer through the DNA photonic structure via steady-state spectroscopy. Data suggests that limiting factors for efficient energy transfer are the sub-obtimal photophysical properties of acceptor dyes, including low quantum yields. These issues may be addressed with improved configurations of QDs, DNA and dyes. The development of biophotonic wire assemblies utilizing the superior photophysical properties of QDs will have widespread application in nanotechnology.

Paper Details

Date Published: 11 February 2011
PDF: 8 pages
Proc. SPIE 7909, Colloidal Quantum Dots/Nanocrystals for Biomedical Applications VI, 79090R (11 February 2011); doi: 10.1117/12.879272
Show Author Affiliations
Kelly Boeneman, U.S. Naval Research Lab. (United States)
Duane E. Prasuhn, U.S. Naval Research Lab. (United States)
Juan B. Blanco-Canosa, The Scripps Research Institute (United States)
Philip E. Dawson, The Scripps Research Institute (United States)
Joseph S. Melinger, U.S. Naval Research Lab. (United States)
Mario Ancona, U.S. Naval Research Lab. (United States)
Michael H. Stewart, U.S. Naval Research Lab. (United States)
Kimihiro Susumu, U.S. Naval Research Lab. (United States)
Alan Huston, U.S. Naval Research Lab. (United States)
Igor L. Medintz, U.S. Naval Research Lab. (United States)


Published in SPIE Proceedings Vol. 7909:
Colloidal Quantum Dots/Nanocrystals for Biomedical Applications VI
Wolfgang J. Parak; Kenji Yamamoto M.D.; Marek Osinski, Editor(s)

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