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Proceedings Paper

A preclinical SPECT camera with depth-of-interaction compensation using a focused-cut scintillator
Author(s): Fares Alhassen; Haris Kudrolli; Bipin Singh; Sangtaek Kim; Youngho Seo; Robert G. Gould; Vivek V. Nagarkar
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Paper Abstract

Preclinical SPECT offers a powerful means to understand the molecular pathways of metabolic activity in animals. SPECT cameras using pinhole collimators offer high resolution that is needed for visualizing small structures in laboratory animals. One of the limitations of pinhole geometries is that increased magnification causes some rays to travel through the scintillator detector at steep angles, introducing parallax errors due to variable depth-of-interaction in the scintillator, especially towards the edges of the detector field of view. These parallax errors ultimately limit the resolution of pinhole preclinical SPECT systems, especially for higher energy isotopes that can easily penetrate through millimeters of scintillator material. A pixellated, focused-cut scintillator, with its pixels laser-cut so that they are collinear with incoming rays, can potentially compensate for these parallax errors and thus open up a new regime of sub-mm preclinical SPECT. We have built a 4-pinhole prototype gamma camera for preclinical SPECT imaging, using an EMCCD camera coupled to a 3 mm thick CsI(Tl) scintillator whose pixels are focused towards each 500 μm-diameter pinhole aperture of the four pinholes. The focused-cut scintillator was fabricated using a laser ablation process that allows for cuts with very high aspect ratios. We present preliminary results from our phantom experiments.

Paper Details

Date Published: 16 March 2011
PDF: 6 pages
Proc. SPIE 7961, Medical Imaging 2011: Physics of Medical Imaging, 796121 (16 March 2011); doi: 10.1117/12.878324
Show Author Affiliations
Fares Alhassen, Univ. of California, San Francisco (United States)
Haris Kudrolli, Radiation Monitoring Devices, Inc. (United States)
Bipin Singh, Radiation Monitoring Devices, Inc. (United States)
Sangtaek Kim, Univ. of California, San Francisco (United States)
Youngho Seo, Univ. of California, San Francisco (United States)
Robert G. Gould, Univ. of California, San Francisco (United States)
Vivek V. Nagarkar, Radiation Monitoring Devices, Inc. (United States)

Published in SPIE Proceedings Vol. 7961:
Medical Imaging 2011: Physics of Medical Imaging
Norbert J. Pelc; Ehsan Samei; Robert M. Nishikawa, Editor(s)

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