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Proceedings Paper

Simulation of brain tumor resection in image-guided neurosurgery
Author(s): Xiaoyao Fan; Songbai Ji; Kathryn Fontaine; Alex Hartov; David Roberts; Keith Paulsen
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Paper Abstract

Preoperative magnetic resonance images are typically used for neuronavigation in image-guided neurosurgery. However, intraoperative brain deformation (e.g., as a result of gravitation, loss of cerebrospinal fluid, retraction, resection, etc.) significantly degrades the accuracy in image guidance, and must be compensated for in order to maintain sufficient accuracy for navigation. Biomechanical finite element models are effective techniques that assimilate intraoperative data and compute whole-brain deformation from which to generate model-updated MR images (uMR) to improve accuracy in intraoperative guidance. To date, most studies have focused on early surgical stages (i.e., after craniotomy and durotomy), whereas simulation of more complex events at later surgical stages has remained to be a challenge using biomechanical models. We have developed a method to simulate partial or complete tumor resection that incorporates intraoperative volumetric ultrasound (US) and stereovision (SV), and the resulting whole-brain deformation was used to generate uMR. The 3D ultrasound and stereovision systems are complimentary to each other because they capture features deeper in the brain beneath the craniotomy and at the exposed cortical surface, respectively. In this paper, we illustrate the application of the proposed method to simulate brain tumor resection at three temporally distinct surgical stages throughout a clinical surgery case using sparse displacement data obtained from both the US and SV systems. We demonstrate that our technique is feasible to produce uMR that agrees well with intraoperative US and SV images after dural opening, after partial tumor resection, and after complete tumor resection. Currently, the computational cost to simulate tumor resection can be up to 30 min because of the need for re-meshing and the trial-and-error approach to refine the amount of tissue resection. However, this approach introduces minimal interruption to the surgical workflow, which suggests the potential for its clinical application with further improvement in computational efficiency.

Paper Details

Date Published: 1 March 2011
PDF: 11 pages
Proc. SPIE 7964, Medical Imaging 2011: Visualization, Image-Guided Procedures, and Modeling, 79640U (1 March 2011); doi: 10.1117/12.878104
Show Author Affiliations
Xiaoyao Fan, Dartmouth College (United States)
Songbai Ji, Dartmouth College (United States)
Kathryn Fontaine, Dartmouth College (United States)
Alex Hartov, Dartmouth College (United States)
Dartmouth Hitchcock Medical Ctr. (United States)
David Roberts, Dartmouth College (United States)
Dartmouth Hitchcock Medical Ctr. (United States)
Keith Paulsen, Dartmouth College (United States)
Dartmouth Hitchcock Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 7964:
Medical Imaging 2011: Visualization, Image-Guided Procedures, and Modeling
Kenneth H. Wong; David R. Holmes III, Editor(s)

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