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Proceedings Paper

Altered cortical anatomical networks in temporal lobe epilepsy
Author(s): Bin Lv; Huiguang He; Jingjing Lu; Wenjing Li; Dai Dai; Meng Li; Zhengyu Jin
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Paper Abstract

Temporal lobe epilepsy (TLE) is one of the most common epilepsy syndromes with focal seizures generated in the left or right temporal lobes. With the magnetic resonance imaging (MRI), many evidences have demonstrated that the abnormalities in hippocampal volume and the distributed atrophies in cortical cortex. However, few studies have investigated if TLE patients have the alternation in the structural networks. In the present study, we used the cortical thickness to establish the morphological connectivity networks, and investigated the network properties using the graph theoretical methods. We found that all the morphological networks exhibited the small-world efficiency in left TLE, right TLE and normal groups. And the betweenness centrality analysis revealed that there were statistical inter-group differences in the right uncus region. Since the right uncus located at the right temporal lobe, these preliminary evidences may suggest that there are topological alternations of the cortical anatomical networks in TLE, especially for the right TLE.

Paper Details

Date Published: 15 March 2011
PDF: 8 pages
Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79652F (15 March 2011); doi: 10.1117/12.877808
Show Author Affiliations
Bin Lv, Institute of Automation (China)
Huiguang He, Institute of Automation (China)
Jingjing Lu, Peking Union Medical College Hospital (China)
Wenjing Li, Institute of Automation (China)
Dai Dai, Institute of Automation (China)
Meng Li, Institute of Automation (China)
Zhengyu Jin, Peking Union Medical College Hospital (China)

Published in SPIE Proceedings Vol. 7965:
Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging
John B. Weaver; Robert C. Molthen, Editor(s)

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